Pure Encapsulations

B-Complex Plus™

Price range: $26.50 through $42.00

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The Promise

Complete B‑Complex blend — full‑spectrum B vitamins

A comprehensive combination of B1, B2, B3, B5, B6, B12, biotin and folate supplied in bioavailable forms.*

Includes active folate

Folate is provided as Metafolin® L‑5‑MTHF, the naturally occurring, directly usable form of folate.

Methylcobalamin B12

Vitamin B12 is supplied as methylcobalamin, the form listed in the formula.

Activated B2 and B6 present

Riboflavin includes riboflavin 5'‑phosphate and B6 includes pyridoxal 5'‑phosphate as activated forms.

Vegetarian capsule and ingredient sourcing

Delivered in a vegetable capsule with several vitamins sourced via corn dextrose fermentation and some ingredients noted as synthetic.

Why It Works

Why these forms matter — Specific ingredient forms and roles

The formula uses recognizable active forms and combinations chosen for direct usability and metabolic support.*

01

Directly usable folate

L‑5‑MTHF bypasses several enzymatic activation steps and is chemically identical to the active folate metabolite.

02

B12 in methylcobalamin form

Methylcobalamin participates in the methionine synthase pathway important for homocysteine metabolism and SAMe production.

03

Niacin variants included

Niacin is provided as niacinamide and 8% inositol hexaniacinate (no‑flush niacin) within the niacin total.

04

B2 and B6 activation support*

Riboflavin helps convert folate and vitamin B6 to their active states while the formula supplies activated B6 as pyridoxal 5'‑phosphate.*

Reviews

Customer Reviews

Your Journey

How to take it — Practical use and cautions

Clear serving guidance, capsule format, and a few precautions to consider.

Serving

Take 1–2 capsules daily

Suggested use is 1–2 capsules per day in divided doses with meals.

Capsule format

Vegetarian capsule

Each dose comes in a vegetable capsule made from cellulose and water.

Precautions

Pregnancy and drug interactions

If pregnant or lactating consult your physician; folic acid may adversely interact with chemotherapeutic drugs.

Product options

Available sizes

This formula is offered in 60‑ and 120‑capsule sizes.

Product education

B Complex Information, Usage, Dosage Recommendations

What Are B Vitamins and What Do They Do?

B-Complex Plus is an exceptional combination of B vitamins, including vitamins B1, B2, B3, B5, B6, B12, biotin, and folic acid (as Metafolin L-5-MTHF), all of which are provided in their optimal bioavailable and functional forms.*

Watch Video About B-Vitamins

B-Vitamins Features Include

Vitamin B1 (thiamine HCl), processing carbohydrates, fat, and protein via its coenzyme form of thiamine pyrophosphate (TPP). Vitamin B1 is required to form adenosine triphosphate (ATP), the key source of energy for the body. Thiamine also promotes neural health.*

Vitamin B2 (riboflavin and riboflavin 5′ phosphate), metabolizing nutrients and participating in electron transport to form ATP. Riboflavin is an integral part of fatty acid catabolism or B-oxidation and helps convert folic acid and vitamins B6 to their active states.*

Vitamin B3 (niacinamide and inositol hexaniacinate), supporting cardiovascular health by mediating healthy lipid and carbohydrate metabolism.*

Vitamin B5 (calcium pantothenate), supporting cardiovascular health. Pantothenic acid is vital in the healthy production, transportation, and breakdown of lipids. Furthermore, this B vitamin promotes the production of the neurotransmitter acetylcholine.*

Vitamin B6 (pyridoxine HCl and pyridoxal 5′ phosphate), supporting amino acid metabolism, nervous system health, and neurotransmitter (i.e. GABA and serotonin) synthesis, which studies have reported may help promote menstrual comfort. Furthermore, pyridoxine supports healthy red blood cells by participating in hemoglobin synthesis and some studies indicate it supports wrist nerve comfort.*

Vitamin B7 also known as Biotin, acts as a coenzyme for the metabolism of fat, carbohydrates and protein and known for healthy hair, nails and skin.*

Vitamin B9 also known as Folic Acid promotes the production of healthy DNA and chromosomes. Adequate folate status is critical for nucleic acid synthesis and neurotransmitter synthesis. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues. It is provided in this formula as Metafolin, the naturally occurring universally metabolized form of folate. Metafolin is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. In conjunction with vitamins B12 and B6, folic acid helps to support healthy homocysteine metabolism. Additionally, this B vitamin is important for the growth and reproduction of red and white blood cells.*

Vitamin B12 (methylcobalamin), supporting healthy nerve cell activity and DNA replication. Vitamin B12 is a vital component of the methionine synthase pathway, which along with folic acid and vitamin B6 supports healthy homocysteine metabolism and S-adenosylmethionine (SAMe) production.*

Uses For B-Complex Plus

These B vitamins play important roles in nearly all of the physiological systems in the body. Some of the key supportive roles include the maintenance of muscle tone in the GI tract, the functioning of the nervous system, and the integrity of skin, hair, and the liver. Furthermore, these compounds are essential for hemoglobin formation, nerve impulse transmissions, mood, hormone synthesis, and energy metabolism.*

What Is The Source of B-Vitamins?

Pure Encapsulations B-Complex Plus formula contains:

Vitamin B1 (thiamine HCl): synthetic Vitamin B2 (riboflavin): corn dextrose fermentation Niacinamide and Inositol hexaniacinate: synthetic Vitamin B5 (calcium pantothenate): synthetic Vitamin B6 (pyridoxal HCl): synthetic Vitamin B12 (methylcobalamin): corn dextrose fermentation Folic acid (Metafolin®, L-5-MTHF): synthetic Biotin: synthetic Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany

Do B-Vitamins Have Any Potential Side Effects Or Precautions?

At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.

Are There Any Potential Drug Interactions With B Vitamins?

Folic acid may adversely interact with chemotheraputic drugs.

When Choosing a Vitamin B Supplement, See Why Pure Encapsulations Is A Great Choice

https://dev.pureprescriptions.com/why-i-choose-pure-encapsulations/

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: 1-2 capsules per day, in divided doses, with meals.
Each vegetable capsule contains:
Ingredients AMT %DV
Thiamine HCl (B1) 100 mg -
Riboflavin (as vitamin B2 and 60% riboflavin 5' phosphate (activated B2)) 12.7 mg -
Vitamin B6 (as pyridoxine HCl and 40% pyridoxal 5' phosphate (activated B6)) 16.7 mg -
Niacin (as niacinamide and 8% inositol hexaniacinate (no-flush niacin)) 108 mg -
Pyridoxal 5' phosphate (activated B6) 10 mg -
Pantothenic acid (as calcium pantothenate) (B5) 100 mg -
Vitamin B12 (as methylcobalamin) 400 mcg -
Folate (as Metafolin®, L-5-MTHF) 667 mcg DFE (L-5-MTHF 400 mcg) 400 mcg -
Biotin 400 mcg -
Other Ingredients: vegetarian capsule (cellulose, water), ascorbyl palmitate
(-) There is no %DV or the manufacturer has not provided this data.

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