THE PROMISE
B vitamins work together. This formula activates them all.
Most B-complex supplements use cheap, unactivated forms that require your liver to convert before they become usable. Activated B-Complex skips that step — delivering the bioactive forms your cells can put to work immediately.
All Eight B Vitamins
B1, B2, B3, B5, B6, B7, B9, and B12 — the complete spectrum in one formula. Every B vitamin plays a distinct role in energy metabolism, neurological health, and cellular repair.*
Activated Forms Only
Methylcobalamin (B12), Pyridoxal-5-Phosphate (B6), and Quatrefolic® (5-MTHF folate) — the bioavailable, active forms your cells can use immediately without conversion.
Quatrefolic® Folate
The leading activated folate form — far superior to folic acid in absorption and utilization. Critical for the ~40% of people with MTHFR gene variants who cannot convert standard folic acid.
Energy + Methylation
B vitamins are essential cofactors for methylation — the biochemical process governing DNA repair, neurotransmitter synthesis, detoxification, and cellular energy production.*
WHY IT WORKS
Eight vitamins. One unified system.
Sustained Energy Production
B vitamins are essential cofactors in the Krebs cycle — converting carbohydrates, fats, and proteins into ATP. Without adequate B vitamins, every cell in your body produces energy less efficiently.*
Neurological & Cognitive Health
B6, B9, and B12 are critical for neurotransmitter synthesis — serotonin, dopamine, and GABA. Deficiency is directly linked to fatigue, brain fog, mood instability, and reduced cognitive wellness.*
Methylation & DNA Repair
The activated folate (5-MTHF) and methylcobalamin in this formula are the rate-limiting cofactors in methylation — one of the most important biochemical processes governing long-term cellular health.*
Heart & Skin Health
B vitamins regulate homocysteine — high levels are a major cardiovascular risk factor. Biotin (B7) and riboflavin (B2) also support skin integrity, hair growth, and nail strength.*
Customer Reviews
Tried, tested,
truly loved.
YOUR METHOD
Make it your method,
not just a habit
Activated B-Complex is designed to fuel your day from the inside out — starting with breakfast and sustaining through your highest-demand hours.
MORNING
Take 1–2 capsules with your morning meal. B vitamins are water-soluble and absorb well with food. Taking with breakfast ensures the energy-metabolizing B vitamins are active during your peak hours.*
WHY IT WORKS
B vitamins activate the enzymes that convert food into cellular energy (ATP) — so morning dosing aligns with your body's highest energy demand window.*
SPLIT DOSE
On high-demand days, take an additional capsule with lunch. B vitamins are water-soluble — any excess is excreted, not stored. A midday dose helps sustain energy metabolism through afternoon hours.*
WHY IT WORKS
B12 and B6 are rate-limiting cofactors for dopamine and serotonin synthesis — supporting mood and cognitive clarity through the afternoon dip most people experience.*
DAILY HABIT
B vitamins work cumulatively. Daily supplementation maintains optimal tissue levels of all eight vitamins — particularly important for B12, which can take weeks to normalize if deficient.*
WHY IT WORKS
Plasma B12 levels stabilize within 2–4 weeks of daily supplementation. Neurological and energy benefits compound over consistent daily use.*
HOW TO TAKE IT
Simple by design. Effective by science.
One to two capsules with breakfast. That's the entire protocol.
What's Inside
What's inside,
and why it matters.
The energy gatekeeper.
As Thiamin HCl — supports nervous system function, energy metabolism, and electrolyte balance across muscle and nerve cells. Essential for converting carbohydrates into ATP.*
Thiamin HCl · 25 mg · 2,083% Daily Value
Thiamin HCl · USA
Powers the electron transport chain.
As Riboflavin-5-Phosphate — the active, coenzyme form. Provides antioxidant activity, supports energy production at the mitochondrial level, and may reduce frequency and duration of occasional head tension.*
Riboflavin-5-Phosphate · 25 mg · 1,923% Daily Value
R5P Active Form · USA
Critical for over 400 enzymatic reactions.
As Niacinamide — supports cholesterol balance, DNA repair, cell signaling, and skin protection from oxidative damage. The flush-free form preferred for daily supplementation.*
Niacinamide · 50 mg · 313% Daily Value
Niacinamide · USA
Synthesizes CoA for every energy pathway.
As D-Calcium Pantothenate — synthesizes Coenzyme A, essential for fat, protein, and carbohydrate metabolism and adrenal hormone production. Supports stress resilience at the cellular level.*
D-Calcium Pantothenate · 100 mg · 2,000% Daily Value
D-Calcium Pantothenate · USA
The active form your brain actually uses.
As Pyridoxal-5-Phosphate (P5P) — the active coenzyme form of B6. Cofactor for neurotransmitter synthesis (serotonin, dopamine, GABA) and immune function. Superior to standard pyridoxine HCl.*
Pyridoxal-5-Phosphate · 25 mg · 1,471% Daily Value
P5P Active Form · USA
Active folate — bypasses the MTHFR block.
As Quatrefolic® 5-MTHF — the active, methylated form directly usable for methylation, DNA synthesis, and neural tube development. Up to 40% of adults carry MTHFR variants that block standard folic acid conversion.*
Quatrefolic® [6S]-5-MTHF · 400 mcg DFE · 100% Daily Value
Quatrefolic® · Italy
The neurologically active form of B12.
As Methylcobalamin — essential for myelin sheath production, red blood cell formation, and cognitive health. The most bioavailable B12 form, directly usable without liver conversion.*
Methylcobalamin · 500 mcg · 20,833% Daily Value
Methylcobalamin · Japan
Essential for fatty acid synthesis and gene expression.
As D-Biotin — critical for fatty acid synthesis, amino acid metabolism, and gene expression. Widely studied for supporting hair, skin, and nail integrity at clinically meaningful doses.*
D-Biotin · 300 mcg · 1,000% Daily Value
D-Biotin · USA
Dr. Devin Ryerson
Founder & Chief Curator · Est. 1999Why It Matters
Built by someone with
personal stakes in it.
Devin started Pure Prescriptions in 1999 after battling Hodgkin's Lymphoma and losing his father to leukemia. That experience made him the most stubborn kind of formulator — one who refuses to ship anything he wouldn't take himself.
Every ingredient here earned its place through clinical evidence, third-party testing, and that same personal lens — the five collagen types, the organic fruiting-body mushrooms, the co-factors. Nothing is decorative.
"Pure Prescriptions has always been more personal than corporate. Built by family. Still independent."
Our StoryYour Journey
What to expect
B vitamins work cumulatively. Here's what customers experience over time.
DAYS 1–7
Initial Energy Shift
Most people notice improved energy within the first week — particularly in the afternoon. Water-soluble B vitamins begin optimizing cellular energy metabolism quickly once tissue levels rise.
ENERGY METABOLISM ACTIVATED
WEEKS 2–4
Mood & Cognitive Lift
B6 and methylcobalamin support serotonin and dopamine synthesis. Improved mood stability, focus, and reduced brain fog become measurable with consistent daily use.
NEUROTRANSMITTER SUPPORT
WEEKS 4–8
Methylation & Metabolism
Full methylation cycle support stabilizes homocysteine levels, optimizes DNA repair, and supports healthy red blood cell production. Cardiovascular markers improve measurably.
METHYLATION · CARDIOVASCULAR
3+ MONTHS
Long-Term Cellular Health
Sustained B vitamin sufficiency supports long-term neurological health, skin and hair integrity, and metabolic resilience — the compounding benefits that make B-Complex foundational.
LONGEVITY · NEUROPROTECTION
RESULTS ARE BEST WITH DAILY USE · MOST CUSTOMERS SEE BENEFITS BY WEEK 12
RESULTS VARY FROM PERSON TO PERSON
The Science
Activated.
Not converted.
Most B-complex formulas use cheap, synthetic forms that your liver must convert before your cells can use them — a process that fails in people with MTHFR variants, liver stress, or absorption issues. Activated B-Complex delivers the end-state, bioavailable forms directly.
- Methylcobalamin B12 — the neuro-active form
- Quatrefolic® 5-MTHF — activated folate
- Pyridoxal-5-Phosphate (P5P) — active B6
- Riboflavin-5-Phosphate — active B2
- No cyanocobalamin; folate and capsule ingredients follow the product label
Read the Science
Have Questions?
Everything you need to know.
Honest answers — no marketing spin. If your question isn’t here, our team responds within one business day.
Standard B-complex formulas use synthetic forms — folic acid, cyanocobalamin — that require your liver to convert them into active forms before your cells can use them. People with MTHFR gene variants, liver stress, or malabsorption issues may not convert these efficiently. Activated B-Complex provides the bioavailable end-state forms directly: methylcobalamin (B12), 5-MTHF folate, and P5P (B6).
Quatrefolic® is the brand name for glucosamine salt of 5-methyltetrahydrofolate — the most bioavailable form of folate available. Unlike synthetic folic acid, it does not require any enzymatic conversion and is directly usable for methylation and DNA synthesis. It’s particularly important for those with MTHFR variants, which affect up to 40% of the population.
Yes — take the second capsule with a meal as part of the label’s 1 capsule twice daily suggested use. B vitamins are water-soluble, so excess is safely excreted. A midday dose can help sustain energy metabolism and neurotransmitter production through the afternoon hours.
Yes — this is completely normal and expected. Riboflavin (B2) is intensely yellow and excreted in urine when B vitamin levels are sufficient. This is a sign the formula is working and being absorbed, not a cause for concern.
This formula contains Quatrefolic® folate. However, always consult your OB or healthcare provider before starting any supplement during pregnancy or nursing.
Doctor’s Protocol
How I’d build your energy foundation.
“Activated B vitamins unlock the methylation cycle. CoQ10 captures the energy those pathways produce. Magnesium ensures every enzymatic reaction fires correctly. Omega-3s protect the neurological infrastructure. Each layer depends on the one before it.”
Dr. Devin Ryerson · Founder, Pure Prescriptions
In Order of Priority
4 Products · 1 Protocol
Energy · Methylation · Neurological Health
Activated B-Complex
Start here. Full-spectrum activated B vitamins — methylcobalamin, Quatrefolic® 5-MTHF, and P5P — in their bioavailable end-state forms. The foundation for energy metabolism and methylation support.
Cellular Energy · Antioxidant
Bioactive Coenzyme Q10
B vitamins and CoQ10 are both rate-limiting cofactors in the mitochondrial electron transport chain — combining them dramatically amplifies cellular energy output.
Deep Recovery · Sleep
Magnesium Glycinate
Magnesium is a cofactor for over 300 enzymatic reactions — including the same ATP-producing pathways that B vitamins support. They work better together.
Brain Health · Cardiovascular
Premium Omega-3 Plus
Omega-3 fatty acids support neuronal membrane integrity, enhancing the neurotransmitter pathways that B vitamins power. A foundational pairing for cognitive and mood health.
Add the full protocol — earn $25 store credit on your next order.
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Orders Shipped
Years in Business
Founded
Owned & Operated
In the USA
