Pure Encapsulations

Folate 5000 Plus

$83.00

SIZE: 60 Capsules

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SKU: FLP56 Category: Tags: , , Product Brand:

The Promise

Active folate plus B vitamins — High‑potency, activated forms

A concentrated folate capsule delivering activated folate together with activated B6 and methylcobalamin.

Contains 5,000 mcg of 5‑MTHF

Each capsule provides 5,000 mcg of folate as Quatrefolic® (6S)-5‑methyltetrahydrofolic acid, glucosamine salt.

Activated B‑vitamin blend

Provides 1,000 mcg methylcobalamin (B12) and 25 mg pyridoxal‑5′‑phosphate (activated B6) in the same capsule.

Vegan, hypoallergenic formulation

Made with hypoallergenic plant fiber and a vegetarian cellulose capsule; ingredients are described as vegan.

Designed to bypass folic acid activation steps

Uses the biologically active 5‑MTHF form so it is directly usable without additional enzymatic activation.

Why It Works

Why this formulation matters — Active chemistry explained

Specific ingredient forms and combinations were chosen to deliver methyl donors and active B vitamins.

01

Quatrefolic® provides the active folate stereoisomer

The product uses Quatrefolic® (6S)-5‑MTHF, the naturally predominant and directly metabolized folate form.

02

Methylcobalamin is the B12 form included

Vitamin B12 is supplied as methylcobalamin, a methylated cobalamin form rather than cyanocobalamin.

03

Pyridoxal‑5′‑phosphate is the activated B6

Vitamin B6 is present as pyridoxal‑5′‑phosphate, the coenzyme form of B6.

04

Combination supports methyl group availability*

Activated folate together with methylcobalamin and P‑5‑P provides methyl groups to support methylation processes.*

Reviews

Customer Reviews

Your Journey

How to use it — Practical steps

Simple daily use with attention to contraindications and practitioner guidance.

Serving size

Take one capsule daily

Suggested use is 1 capsule daily with a meal, or follow a health professional's directions.

Format & preparation

Vegetarian capsule, no special prep

Capsules are vegetarian cellulose and require no mixing or refrigeration.

Dietary fit

Suitable for vegan or hypoallergenic needs

Ingredients include hypoallergenic plant fiber and vegan‑derived components such as corn fermentation for certain vitamins.

Precautions & interactions

Check pregnancy and medication interactions

Consult a physician if pregnant or lactating, and be aware folate may interact with some chemotherapeutic drugs.

Product education

Folate 5000 Plus Information, Uses and Dosage Recommendations

Folate is provided in this formula as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate. This form is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations.*

Folate 5,000 Plus Special Features

  • 5,000 mcg of activated folate per capsule
  • Combination o factivated B vitamins
  • Made with hypoallergenic, vegan ingredients

Uses for Folate 5,000 Plus

Cellular Health: Optimal levels of folate, vitamin B6, and vitamin B12 have been associated with cellular, cardiovascular, neurological and psychological health. 5-MTHF is the predominant, naturally occurring form of folate in food. As genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent, 5-MTHF bypasses several enzymatic activation steps, offering all of the benefits of folic acid regardless of functional or genetic variations. This form offers superior bioavailability and can be directly used in a diverse array of essential methylation reactions. In a double- blind, randomized, placebo-controlled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid. Activated B vitamins provide methyl groups to support healthy methylation, a key regulator of genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism.*

Neuronal Health: Research suggests that B vitamins help maintain healthy nervous system function. In a randomized controlled study,
a combination of methylfolate, methycobalamin and pyridoxal-5- phosphate promoted healthy epidermal nerve fiber density and nerve comfort. These vitamins also enhance healthy endothelial function and play a vital role in the metabolism of homocysteine.*

MTHFR

What Is The Source of 5-MTHFR?

Quatrefolic® (6S)-5-Methyltetrahydrofolic acid, glucosamine salt, and pyridoxal 5’ phosphate are synthetic. Glucosamine and methylcobalamin are derived from corn dextrose fermentation. Hypoallergenic plant fiber is derived from pine cellulose.

Dosage Recommendations For Folate 5000 Plus

Pure Encapsulations® recommends 1 capsule daily, with a meal, or as directed by a health professional.

Are There Any Potential Side Effects Or Precautions?

If pregnant or lactating, consult your physician before taking this product. At this time, there are no known side effects or precautions. Consult your physician for more information.

Are There Any Potential Drug Interactions?

Folate may adversely interact with chemotherapeutic drugs. Consult your physician for more information.

Quatrefolic® is a registered trademark of Gnosis S.p.A. Patent No. 7,947,662

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: 1 capsule daily, with a meal, or as directed by a health professional
Each vegetable capsule contains:
Ingredients AMT %DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid, glucosamine salt) 5,000 mcg -
Vitamin B12 (as methylcobalamin) 1,000 mcg -
Vitamin B6 (as pyridoxal 5’ phosphate (activated B6)) 25 mg. -
Other Ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water)
(-) There is no %DV or the manufacturer has not provided this data.

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