THE PROMISE
The most complete natural cholesterol formula available.
Red Yeast Rice+ is the only formula combining organic red yeast rice with Cholesstrinol™ and COQSOURCE® VESIsorb® CoQ10 in a single capsule — three independently proven cardiovascular ingredients with a combined body of clinical evidence no other red yeast rice product can match.
Cholesstrinol™ Blend
The patented PMF-SOURCE® and TOCOSOURCE® combination — clinically shown to reduce total cholesterol by 30%, LDL by 27%, and triglycerides by 34% versus placebo in peer-reviewed trials.*
VESIsorb® CoQ10
COQSOURCE® powered by VESIsorb® delivers CoQ10 at dramatically higher bioavailability than standard softgels. Recognized globally as the most advanced CoQ10 delivery system available.
Organic Red Yeast Rice
Rigorously tested for therapeutic monacolin K levels and confirmed safe citrin profiles. Unlike unverified competitors, every batch is third-party verified for both potency and safety.
Practitioner Formulated
Designed by Dr. Devin Ryerson in San Diego since 1999. Every ingredient was selected for clinical evidence, not cost. Third-party tested for purity and potency on every batch.
WHY IT WORKS
Four mechanisms, one formula.
LDL & Total Cholesterol
Monacolin K in organic red yeast rice inhibits HMG-CoA reductase — an enzyme involved in LDL production in the liver. Cholesstrinol™ amplifies this effect: clinical trials showed a 30% reduction in total cholesterol and 27% reduction in LDL compared to placebo.*
Triglycerides & HDL Balance
Cholesstrinol™'s PMF-SOURCE® (polymethoxylated flavones from citrus) has been clinically shown to reduce triglycerides by 34% while simultaneously increasing HDL cholesterol by 4% — resulting in a 29% improvement in the LDL:HDL ratio, a key cardiovascular risk marker.*
Mitochondrial Energy & Heart Support
COQSOURCE® via VESIsorb® delivers CoQ10 directly into the bloodstream at clinically superior concentrations. CoQ10 is essential for cardiac muscle energy production (ATP synthesis) and acts as a powerful antioxidant protecting against oxidative damage to arterial walls and heart tissue.*
Bioavailability & Cellular Uptake
VESIsorb® is a patented colloidal droplet delivery system that has been shown in pharmacokinetic studies to dramatically improve absorption of poorly-absorbed lipophilic compounds like CoQ10. Studies show 3–6× higher blood plasma concentrations versus standard softgels — less wasted, more delivered.
Customer Reviews
Tried, tested,
truly loved.
YOUR PROTOCOL
When to take it,
and why it matters
Red Yeast Rice+ is most effective taken with an evening meal containing healthy fats. Consistent daily use over 8–12 weeks produces the measurable lipid improvements shown in clinical trials. Monitor results with your physician.
WITH EVENING MEAL
Take 2 capsules with your evening meal. The liver produces the most cholesterol overnight — taking Red Yeast Rice+ with dinner ensures monacolin K is present during peak cholesterol synthesis, maximizing its inhibitory effect on HMG-CoA reductase.
WHY IT WORKS
The timing of HMG-CoA reductase inhibition matters clinically. Evening dosing aligns with the liver's peak cholesterol production window — the same rationale behind why statins are commonly prescribed at bedtime.
WITH A FAT-CONTAINING MEAL
The VESIsorb® CoQ10 delivery system uses a colloidal droplet technology that functions optimally in the presence of dietary lipids. Taking this supplement with a meal containing healthy fats — olive oil, avocado, nuts — maximizes CoQ10 bioavailability.
WHY IT WORKS
VESIsorb® self-assembles into colloidal droplets that dramatically increase the surface area available for intestinal absorption. The presence of bile (secreted in response to dietary fat) further enhances this colloidal absorption pathway.
DAILY CONSISTENCY
Cholesterol management with natural compounds is cumulative — clinical improvements in the Cholesstrinol™ trials were measured at 4 and 8 weeks of continuous use. Sporadic supplementation produces minimal results; consistent daily use is essential.
WHY IT WORKS
The 30% total cholesterol reduction demonstrated in Cholesstrinol™ trials required 8 weeks of consistent daily dosing. HMG-CoA reductase inhibition and lipid panel normalization are gradual, cumulative physiological processes — not acute responses.
SUGGESTED USE
Two capsules. With dinner. Every day.
Take 2 capsules with your evening meal. Do not exceed the recommended serving. Consult your physician before use if you are on cholesterol-lowering medications.
Full-Spectrum Formula
What's inside,
and why it matters.
Monacolin K — nature's statin equivalent.
Organic red yeast rice fermented with Monascus purpureus contains monacolin K, a naturally occurring compound structurally identical to lovastatin. It inhibits HMG-CoA reductase — the enzyme responsible for hepatic cholesterol synthesis — reducing LDL production at the source. Rigorously tested for therapeutic monacolin K levels and confirmed safe citrin profiles.
Organic Red Yeast Rice (Monascus purpureus) · 1,200 mg · Monacolin K standardized · Citrin tested safe · USDA Organic
Monascus purpureus · Organic
Polymethoxylated flavones — the clinical differentiator.
PMF-SOURCE® delivers polymethoxylated flavones (PMFs) from citrus peel — a class of bioactive compounds with robust clinical evidence for cholesterol and triglyceride support. In peer-reviewed trials, PMFs produced a 27% reduction in LDL, 34% reduction in triglycerides, and 4% increase in HDL versus placebo.
Cholesstrinol™ Blend · PMF-SOURCE® (citrus PMFs) + TOCOSOURCE® (palm tocotrienols) · Patented combination · Clinical dose
Citrus Peel Extract · Patented
Palm tocotrienols — the cholesterol-lowering vitamin E.
TOCOSOURCE® provides a concentrated source of delta- and gamma-tocotrienols, the most biologically active forms of vitamin E. Unlike tocopherols, tocotrienols suppress HMG-CoA reductase through a post-transcriptional mechanism, providing additive cholesterol support alongside the PMFs and red yeast rice in this formula.
TOCOSOURCE® Palm Tocotrienol Complex · Delta- and gamma-tocotrienols · Non-GMO palm source
Palm Tocotrienol Complex
The most bioavailable CoQ10 in the world.
COQSOURCE® powered by VESIsorb® is widely recognized as the most advanced CoQ10 formulation available. VESIsorb® is a self-assembling colloidal delivery system that creates nanoscale droplets, dramatically increasing intestinal absorption and blood plasma CoQ10 concentrations — studies show 3–6× higher levels versus standard CoQ10 softgels.
COQSOURCE® Coenzyme Q10 (VESIsorb® delivery system) · Colloidal droplet technology · Referenced in peer-reviewed pharmacokinetic literature
VESIsorb® · Switzerland
Dr. Devin Ryerson
Founder & Chief Curator · Est. 1999Why It Matters
Built by someone with
personal stakes in it.
Devin started Pure Prescriptions in 1999 after battling Hodgkin's Lymphoma and losing his father to leukemia. That experience made him the most stubborn kind of formulator — one who refuses to ship anything he wouldn't take himself.
Every ingredient here earned its place through clinical evidence, third-party testing, and that same personal lens — the five collagen types, the organic fruiting-body mushrooms, the co-factors. Nothing is decorative.
"Pure Prescriptions has always been more personal than corporate. Built by family. Still independent."
Our StoryYour Journey
What to expect
Cholesterol management is cumulative. Here's what the clinical evidence shows week by week.
WEEK 1–2
HMG-CoA Inhibition Begins
Monacolin K begins inhibiting HMG-CoA reductase in the liver, reducing de novo cholesterol synthesis. VESIsorb® CoQ10 reaches therapeutic plasma concentrations within days. Energy and cellular protection benefits of CoQ10 emerge first.
COQ10 ACTIVE · RYR ENGAGED
WEEK 4
Early Lipid Changes
Preliminary measurable changes in LDL and total cholesterol begin. PMF-SOURCE® from Cholesstrinol™ starts modulating triglyceride synthesis pathways. Some users report improved energy levels as mitochondrial CoQ10 support accumulates.
EARLY CHOLESTEROL SHIFTS
WEEK 8
Clinical Trial Endpoint
The 8-week mark is when peer-reviewed Cholesstrinol™ trials detected significant lipid improvements. Total cholesterol down ~30%, LDL ~27%, triglycerides ~34% versus placebo. This is the first checkpoint to test with your physician.
CLINICAL BENCHMARK REACHED
WEEK 12+
Sustained Cardiovascular Support
All three active complexes are fully integrated into daily cardiovascular physiology. LDL:HDL ratio improvements stabilize. Continued daily use maintains lipid panel benefits and extends antioxidant protection of CoQ10 to cardiac and vascular tissue.
FULL PROTOCOL BENEFIT
RESULTS ARE BEST WITH DAILY USE · CONSULT YOUR PHYSICIAN TO MONITOR LIPID PANEL PROGRESS
Results vary from person to person.
The Science
Why most red yeast rice
products fall dangerously short.
The red yeast rice market is saturated with unverified products that fail on two counts: unstandardized monacolin K (inconsistent potency) and no CoQ10 (HMG-CoA inhibition depletes CoQ10 in the same pathway statins do). Red Yeast Rice+ is the only formula that addresses both — with patented Cholesstrinol™ and VESIsorb® CoQ10.
- Organic RYR with verified therapeutic monacolin K levels
- Cholesstrinol™ — 30% total cholesterol reduction in trials
- COQSOURCE® VESIsorb® CoQ10 — 3–6× standard bioavailability
- Third-party tested for citrin safety on every batch
VESIsorb® · Cholesstrinol™ · Patented
Have Questions?
Everything you need to know.
Honest answers — no marketing spin. If your question isn’t here, our team responds within one business day.
Red Yeast Rice+ is the only formula combining organic red yeast rice (with verified therapeutic monacolin K and confirmed safe citrin levels) with patented Cholesstrinol™ (PMF-SOURCE® + TOCOSOURCE®) and COQSOURCE® CoQ10 via VESIsorb® delivery. No other product in the market contains this combination of independently clinically proven ingredients.
Red yeast rice contains monacolin K, which has a similar mechanism to statin drugs (HMG-CoA reductase inhibition). You should not take this product alongside prescription statins without explicit guidance from your physician, as combined use may amplify effects and increase risk of side effects. Always consult your doctor before combining any cholesterol-lowering supplements or medications.
HMG-CoA reductase inhibitors (both statins and monacolin K) deplete cellular CoQ10 — a compound critical for mitochondrial energy production and cardiac function. Including CoQ10 directly counteracts this depletion. VESIsorb® is included because standard CoQ10 has very poor bioavailability — VESIsorb® colloidal delivery shows 3–6× higher blood plasma concentrations in pharmacokinetic studies.
The Cholesstrinol™ clinical trials measured significant lipid improvements at the 8-week mark — including 30% reduction in total cholesterol and 27% reduction in LDL versus placebo. Early CoQ10 energy benefits may be noticed within 2–3 weeks. We recommend testing your lipid panel with your physician before starting and again at 8–12 weeks.
Cholesstrinol™ is a patented blend of PMF-SOURCE® (polymethoxylated flavones from citrus peel) and TOCOSOURCE® (palm tocotrienols). In peer-reviewed clinical trials, this combination produced a 30% reduction in total cholesterol, 27% reduction in LDL, 34% reduction in triglycerides, and 4% increase in HDL versus placebo — a clinically significant improvement in the overall LDL:HDL ratio.
Yes. The red yeast rice in this formula is USDA-certified organic and every batch is third-party tested to confirm therapeutic levels of monacolin K and safe citrin profiles. Citrin is a naturally occurring mycotoxin in some red yeast rice products — its presence at unsafe levels is a concern with unverified brands. Our testing ensures it is below safe thresholds in every batch.
Red Yeast Rice+ pairs well with our Premium Omega-3 Plus (EPA/DHA for additional triglyceride support and anti-inflammatory benefits), Magnesium Glycinate (supports healthy blood pressure and vascular tone), and Bioactive CoQ10 if additional CoQ10 supplementation is desired. Discuss the full protocol with your practitioner.
Doctor’s Protocol
How I’d build your cardiovascular foundation.
“Red Yeast Rice+ handles the LDL and triglyceride side of the equation. Omega-3 adds independent triglyceride support and reduces inflammation. Magnesium addresses vascular tone and blood pressure. CoQ10 protects cardiac mitochondria. Together these form a complete, evidence-based cardiovascular foundation.”
In Order of Priority
4 Products · 1 Protocol
Cholesterol · Triglycerides · CoQ10
Red Yeast Rice+
Start here. The only red yeast rice formula with patented Cholesstrinol™ and VESIsorb® CoQ10 — three independently clinically proven cardiovascular ingredients in a single daily serving.
VESIsorb® · Triglyceride Support
Premium Omega-3 Plus
EPA and DHA provide additional triglyceride-lowering and anti-inflammatory support that complements Red Yeast Rice+. Together they address both LDL reduction and triglyceride management through independent, synergistic mechanisms.
Vascular Tone · Blood Pressure
Magnesium Glycinate
Magnesium deficiency is common and directly impairs vascular tone, blood pressure regulation, and cardiac rhythm. Magnesium glycinate supports cardiovascular health through pathways independent of cholesterol — completing a well-rounded cardiac protocol.
Mitochondrial · Cardiac Energy
Bioactive Coenzyme Q10
For patients who want maximum CoQ10 support above and beyond what is included in Red Yeast Rice+. Additional CoQ10 provides deeper mitochondrial protection, supports heart failure symptoms, and provides robust antioxidant defense for vascular tissue.
Add the full protocol — earn $25 store credit on your next order.
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