Pure Encapsulations

Folate 5000

$73.00

SIZE: 60 Capsules

Out of stock

The Promise

Active folate, ready to use — 5-MTHF as the ingredient

Provides the biologically active form of folate so your body can use it directly.

High-strength dose

Each capsule supplies 5,000 mcg of folate (as L‑5‑MTHF/Metafolin®).

Activated form

Contains 5‑methyltetrahydrofolate (5‑MTHF), the naturally occurring, universally metabolized form of folate.

Hypoallergenic & vegan

Formulated with hypoallergenic plant fiber and a vegetarian cellulose capsule.

Simple daily regimen

Recommended use is one capsule daily with a meal or as directed by a health professional.

Why It Works

Why this folate is different — active, bioavailable, and standardized*

The product uses Metafolin® L‑5‑MTHF, a standardized, bioactive folate form favored when direct utilization is desired.

01

Bypasses activation steps

L‑5‑MTHF does not require the enzymatic activation steps that folic acid does, allowing direct use in methylation reactions.

02

Superior accumulation

Clinical comparison showed greater accumulation of 5‑MTHF in red blood cells versus equivalent folic acid doses.

03

Supports core biochemical roles*

This folate form donates methyl groups used in nucleic acid and neurotransmitter synthesis.

04

Trademarked source

The folate is provided as Metafolin®, a registered L‑5‑MTHF ingredient.

Reviews

Customer Reviews

Your Journey

How to take it — simple daily use and precautions

One capsule daily with a meal is the suggested serving; consult a health professional for personalized guidance.

Serving

Take one capsule daily

Follow the suggested use of 1 capsule per day with a meal.

Format & fit

Vegan-friendly capsule

Capsule and excipients are plant‑based and hypoallergenic.

Timing & routine

Take with food

For routine use, take the capsule with a meal to align with daily habits.

Safety

Consult if undergoing chemotherapy

Consult your physician if you are undergoing chemotherapy.

Product education

 Folate 5,000 Information, Usage & Dosage

The folate is provided in this formula as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate. This form is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations.*

Folate 5,000 Special Features

  • 5,000 mcg of activated folate per capsule
  • Made with hypoallergenic, vegan ingredients

Uses for Folate 5,000

Cellular Health: An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. 5-MTHF is the naturally occurring, universally metabolized and active form of folate. As such, it can be directly used in a diverse array of essential methylation reactions.

Additionally, clinical evidence indicates that the bioavailability of 5-MTHF is superior to folic acid. In a double-blind, randomized, placebo-controlled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid. Adequate folate status is critical for nucleic acid synthesis and neurotransmitter synthesis. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues.*

 MTHFR

What Is The Source of Folate?

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

Folate 5,000 Dosage Recommendations

Pure Encapsulations® recommends 1 capsule daily, with a meal, or as directed by a health professional.

Are There Any Potential Side Effects Or Precautions with Folate?

If pregnant or lactating, consult your physician before taking this product. At this time, there are no known side effects or precautions. Consult your physician for more information.

Are There Any Potential Drug Interactions with Folate?

Folate may adversely interact with chemotherapeutic drugs. Consult your physician for more information.

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: 1 capsule daily, with a meal, or as directed by a health professional
Each vegetable capsule contains:
Ingredients AMT %DV
Folate (as Metafolin®, L-5-MTHF)8,333 mcg DFE  5,000 mcg -
Other Ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water)
(-) There is no %DV or the manufacturer has not provided this data.

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