THE PROMISE
25% trans-resveratrol. The active form. The right matrix.
The French Paradox — favorable cardiovascular health despite a fat-rich diet — sparked decades of research into red wine polyphenols and resveratrol. Purevinol-25 delivers the concentrated result: ResVinol-25™ standardized to the biologically active trans-isomer, with the full polyphenol matrix found in red wine, in a single daily capsule.
ResVinol-25™ Proprietary Extract
Our resveratrol features ResVinol-25™ — a standardized, proprietary extract delivering 25% trans-resveratrol (the most biologically active isomer) and 20% red wine polyphenols. Not all resveratrol is equal — form and standardization matter critically.
Trans-Resveratrol Form
Standardized to the trans-isomer — the biologically active configuration. The cis-isomer found in cheaper products has minimal receptor affinity. Only trans-resveratrol activates sirtuins (SIRT1) and exerts the anti-aging benefits studied in clinical literature.*
Red Wine Polyphenol Matrix
Beyond resveratrol, each capsule delivers the equivalent of 35 glasses of red wine in beneficial polyphenols — including anthocyanins and flavonoids. These compounds act synergistically, providing broader cardiovascular and antioxidant support than isolated resveratrol alone.*
Practitioner Formulated
Certified Kosher, Non-GMO, Non-irradiated, and ETO-free. Pesticide-screened to USP 561 standards. Manufactured at an audited GMP facility. Every batch meets the standards Dr. Ryerson established when founding Pure Prescriptions in 1999.
WHY IT WORKS
Four pathways, one formula.
Sirtuin Activation & Longevity Pathways
Trans-resveratrol is a potent activator of SIRT1 — a sirtuin enzyme that regulates cellular aging, DNA repair, and metabolic efficiency. SIRT1 activation mimics the cellular effects of caloric restriction, one of the most well-studied longevity interventions.* ResVinol-25™ delivers the standardized trans-isomer dose required for meaningful sirtuin activation.
Cardiovascular & Endothelial Support
Red wine polyphenols and resveratrol improve endothelial function — the health of the cells lining blood vessel walls. Studies show resveratrol supports healthy LDL composition, supports vascular function, and promotes nitric oxide production.* This vascular support profile is the scientific basis of the original French Paradox observation.*
Antioxidant & Anti-Inflammatory Defense
Resveratrol inhibits NF-κB — the master regulator of inflammatory gene expression. It also scavenges free radicals directly. The combination of trans-resveratrol and red wine polyphenols (anthocyanins, flavonoids) provides a broader antioxidant spectrum than isolated resveratrol alone, protecting DNA, mitochondria, and cell membranes.*
Glucose Metabolism & Metabolic Support
Resveratrol activates AMPK — the cellular energy sensor that improves insulin sensitivity and glucose uptake. Research in both animal models and human trials shows meaningful support for metabolic markers with consistent resveratrol supplementation.* This makes it particularly valuable for individuals managing metabolic health.
Customer Reviews
Tried, tested,
truly loved.
Your Protocol
When to take it,
and why it matters
Resveratrol is best absorbed with a small amount of dietary fat. Once daily is the standard protocol used in clinical research. Consistency over weeks is what produces meaningful physiological change — not single-dose acute effects.
With Morning Coffee
Take one capsule with your morning beverage. Resveratrol is most commonly studied as a once-daily supplement. Taking it in the morning pairs naturally with other antioxidant-rich habits — green tea, berries — that amplify its polyphenol activity.
Why it works
SIRT1 activation and AMPK signaling are most active in a metabolically active state. Morning dosing ensures resveratrol is present during the period of greatest metabolic activity.
With a Fatty Meal
Resveratrol’s bioavailability improves when taken with a meal containing healthy fats — olive oil, nuts, or avocado. The lipid environment enhances intestinal absorption and may extend the time resveratrol and its metabolites remain in circulation.
Why it works
Trans-resveratrol has relatively short plasma half-life. Taking it with dietary fat slows gastric emptying and extends the absorption window, keeping active concentrations higher for longer.
Daily Consistency
The anti-aging and cardiovascular effects of resveratrol are the product of months of consistent SIRT1 modulation and antioxidant activity — not acute responses. Daily use for 8–12 weeks is the minimum timeframe for meaningful physiological benefit.
Why it works
SIRT1-mediated effects on gene expression, mitochondrial biogenesis, and inflammatory pathway suppression are epigenetic changes that require sustained polyphenol exposure to establish and maintain.
Suggested Use
One capsule. With food. Every day.
As a dietary supplement, take 1 capsule daily or as recommended by a qualified healthcare professional. Best taken with a meal or as directed by your practitioner.
Full-Spectrum Formula
What's inside,
and why it matters.
The biologically active form — standardized, not estimated.
ResVinol-25™ is a proprietary extract standardized to 25% trans-resveratrol — the biologically active cis/trans isomer that binds SIRT1 and exerts anti-aging, cardiovascular support, and anti-inflammatory effects.* The trans-isomer is specifically required; cis-resveratrol has negligible biological activity. Derived from Polygonum cuspidatum root — the highest-potency botanical source.
ResVinol-25™ Proprietary Extract · 25% trans-Resveratrol · 100mg extract = 25mg active trans-resveratrol
Polygonum cuspidatum root · HPLC verified
The French Paradox in a capsule.
Each capsule delivers 20% red wine polyphenols — the class of compounds responsible for wine's cardiovascular support reputation. This matrix includes anthocyanins, proanthocyanidins, quercetin, and catechins from Vitis vinifera (grape). These polyphenols potentiate resveratrol's effects through independent antioxidant and anti-inflammatory mechanisms.
Red Wine Polyphenols · 20% standardized · Vitis vinifera · Equivalent to 35 glasses of red wine per capsule
Vitis vinifera grapes · France
Dr. Devin Ryerson
Founder & Chief Curator · Est. 1999Why It Matters
Built by someone with
personal stakes in it.
Devin started Pure Prescriptions in 1999 after battling Hodgkin's Lymphoma and losing his father to leukemia. That experience made him the most stubborn kind of formulator — one who refuses to ship anything he wouldn't take himself.
Every ingredient here earned its place through clinical evidence, third-party testing, and that same personal lens — the five collagen types, the organic fruiting-body mushrooms, the co-factors. Nothing is decorative.
"Pure Prescriptions has always been more personal than corporate. Built by family. Still independent."
Our StoryYour Journey
What to expect
Resveratrol works by modulating gene expression. These are cumulative, progressive changes — not overnight effects.
WEEK 1–2
Energy & Cellular Uptake
Trans-resveratrol begins activating SIRT1 and AMPK pathways. Many users report increased energy levels within the first week as mitochondrial efficiency improves.* Red wine polyphenols are absorbed and begin modulating antioxidant gene expression.
ENERGY · SIRT1 ENGAGED
WEEK 4
Antioxidant & Inflammatory Balance
NF-κB inflammatory pathway suppression accumulates with consistent dosing. Users report improved skin tone and reduced oxidative stress markers. Endothelial function improvements begin as resveratrol metabolites modulate nitric oxide production.*
ANTIOXIDANT ACTIVITY
WEEK 8
Cardiovascular & Metabolic Markers
The 8-week mark is when meaningful changes in cardiovascular and metabolic markers become apparent. Users monitoring vascular health often notice favorable changes. Insulin sensitivity and glucose metabolism benefits accumulate with consistent AMPK activation.*
CARDIOVASCULAR MARKERS
WEEK 12+
Full Longevity Protocol Benefit
Sustained SIRT1 activation produces epigenetic changes associated with healthy aging — improved DNA repair capacity, mitochondrial biogenesis, and cellular stress resistance.* These are the long-term benefits that distinguish resveratrol from acute antioxidants.
LONGEVITY PATHWAYS ACTIVE
RESULTS ARE CUMULATIVE · MOST CUSTOMERS SEE MEANINGFUL BENEFIT BY WEEK 8–12
Results vary from person to person.
The Science
Why most resveratrol products
don’t actually work.
The resveratrol market is full of products with low-potency, unstandardized extracts — or worse, the biologically inactive cis-isomer. Only trans-resveratrol activates SIRT1 and the longevity pathways studied in clinical research. ResVinol-25™ is standardized to 25% trans-resveratrol with analytical HPLC verification — the only form worth taking.
- — ResVinol-25™ standardized to 25% trans-resveratrol (HPLC verified)
- — Full red wine polyphenol matrix — 20% standardized
- — Equivalent to 35 glasses of red wine per capsule
- — Certified Kosher, Non-GMO, Non-irradiated, ETO-free
ResVinol-25™ · Vitis vinifera · Polygonum cuspidatum
Have Questions?
Everything you need to know.
Honest answers — no marketing spin. If your question isn’t here, our team responds within one business day.
ResVinol-25™ is a proprietary resveratrol extract standardized to 25% trans-resveratrol and 20% red wine polyphenols — verified by HPLC analysis. Unlike cheap extracts with unstated or low trans-resveratrol content, ResVinol-25™ guarantees the active isomer is present at the clinically studied concentration. The trans-isomer is required for SIRT1 activation and other reported benefits.
Trans-resveratrol is the biologically active form. It has the correct molecular configuration to bind SIRT1 and SIRT2 (longevity-associated sirtuin enzymes) and to exert antioxidant, anti-inflammatory, and cardioprotective effects. Cis-resveratrol is a geometric isomer with very different receptor binding — it has minimal biological activity. Many cheap resveratrol products do not specify which form they use.
Each 100mg capsule of ResVinol-25™ contains the same concentration of beneficial polyphenols found in approximately 35 glasses of red wine — without the alcohol, sugar, or calories. This is a meaningful comparison: researchers attribute the French Paradox (low cardiac disease despite high saturated fat diet) partly to the regular polyphenol intake from moderate red wine consumption.
Some customers report increased energy within the first week. More significant effects — on energy, skin, and cardiovascular markers — are typically noticed after 4–8 weeks of consistent daily use. Resveratrol works by modulating gene expression and cellular signaling pathways, which are gradual, cumulative processes.
Purevinol-25 pairs well with our Bioactive CoQ10 (synergistic antioxidant and mitochondrial protection), Premium Omega-3 Plus (cardiovascular support), and Daily Multivitamin. These address cardiovascular health through complementary mechanisms. Consult your physician if you take anticoagulant medications, as resveratrol may have mild blood-thinning effects.
Yes. Our resveratrol is certified Kosher, Non-GMO, Non-irradiated, and ETO-free. It is pesticide-screened to USP 561 standards and analyzed by both HPLC (for trans-resveratrol standardization) and Folin-Ciocalteau (for total polyphenols). Produced in an ENI and audited GMP-compliant facility.
Doctor’s Protocol
How I’d build your longevity & cardiovascular foundation.
“Resveratrol provides the SIRT1 activation signal. CoQ10 provides the mitochondrial energy substrate. Omega-3 handles the inflammatory and cardiovascular side. Collagen captures resveratrol’s pro-collagen synthesis signaling. Together these are the four pillars of a science-based longevity and anti-aging foundation.”
In Order of Priority
4 Products · 1 Protocol
Longevity · Cardiovascular · Antioxidant
Resveratrol
Start here. ResVinol-25™ standardized to 25% trans-resveratrol and 20% red wine polyphenols — the most complete resveratrol formula for SIRT1 activation, cardiovascular support, and cellular anti-aging.
Mitochondrial · Antioxidant
Bioactive Coenzyme Q10
Resveratrol and CoQ10 work synergistically at the mitochondrial level — resveratrol activates SIRT1 and PGC-1α (mitochondrial biogenesis regulators) while CoQ10 provides the electrons for ATP synthesis. Together they constitute the most evidence-based mitochondrial longevity stack available.
VESIsorb® · Cardiovascular
Premium Omega-3 Plus
EPA and DHA address cardiovascular health through mechanisms independent of resveratrol — triglyceride reduction, anti-inflammatory resolution pathways, and endothelial protection. Together they provide a comprehensive multi-mechanism cardiovascular protocol.
Skin · Anti-Aging · Longevity
Perfect Collagen®+ Vitamin C
Resveratrol stimulates collagen synthesis through SIRT1-mediated pathways while also protecting existing collagen from oxidative degradation. Combining with Perfect Collagen provides both the structural substrate and the cellular signaling to maximize skin and tissue collagen levels.
Add the full protocol — earn $25 store credit on your next order.
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