The Promise
Absorb more.
Live better.
Premium Omega-3 Plus combines high-concentration EPA+DHA fish oil — molecularly distilled for purity — with Vitamin D3, Vitamin K2, and VESIsorb® delivery technology. Practitioner-formulated. Zero fishy aftertaste. Zero compromise.
Brain & Cognition
480mg DHA per serving — the dominant structural fatty acid in neuronal membranes. Supports cognitive clarity, focus, and the membrane integrity that declines with age.*
Cardiovascular Health
190mg EPA — a precursor to specialized pro-resolving mediators that actively resolve systemic inflammation. Well-documented support for healthy triglycerides and blood pressure.*
VESIsorb® Technology
A self-emulsifying colloidal delivery system that creates dramatically improved absorption without requiring a full fatty meal. The same technology used in our Bioactive CoQ10.
D3 + K2 Included
Vitamin D3 and K2 work synergistically — D3 increases calcium absorption, K2 directs it into bones. Both are fat-soluble and benefit from the same enhanced delivery system.*
Why It Works
Whole Body Longevity
01
Cardiovascular Support
EPA supports healthy triglyceride levels, reduces systemic inflammation, and helps maintain blood pressure. Among the most extensively studied effects in nutritional medicine — thousands of peer-reviewed studies with consistent outcomes.*
02
Brain Structure & Cognition
DHA is the dominant structural fatty acid in neuronal membranes. Brain cells are 60% fat by dry weight, and DHA is the primary component of neuronal phospholipids. Supports cognitive clarity, focus, and the membrane fluidity that declines with age.*
03
Inflammation Resolution
EPA is a precursor to specialized pro-resolving mediators — lipoxins, resolvins, and protectins. These compounds actively resolve inflammation rather than just suppressing it. A meaningful distinction for long-term cellular and joint health.*
04
Skin & Cellular Health
Omega-3s help maintain skin hydration and barrier function, and may reduce the impact of UV-induced damage. Many people notice a meaningful difference in skin texture within 4–6 weeks of consistent daily use.*
Customer Reviews
Tried, tested,
truly loved.
Your Method
Make it a method,
not just a habit
A habit is showing up every day. A method is showing up the right way — the right dose, at the right moment, for long enough to feel the difference. Three steps below.
With Meals
Omega-3s are fat-soluble and absorb best with dietary fat. Take 2 softgels with your largest meal of the day — typically lunch or dinner. VESIsorb® technology further enhances absorption even on lighter meals, but food always helps.
Why it works
VESIsorb creates a colloidal dispersion in the gut — dramatically improving bioavailability without requiring a high-fat meal.
Daily Dose
Two softgels deliver the full clinical dose: 480mg DHA, 190mg EPA, along with Vitamin D3 and K2. Take both together rather than splitting the dose — co-administration of these fat-soluble nutrients improves overall uptake.
Why it works
480mg DHA + 190mg EPA per serving — above the threshold used in most clinical studies demonstrating measurable cardiovascular and cognitive effects.
Long-Term
Omega-3s are not acute — they build in tissue over time. Joint and skin benefits typically become noticeable at 4–6 weeks. Cardiovascular marker improvements are measurable at 8–12 weeks. Evaluate after a full protocol, not after a week.
Why it works
Omega-3 Index levels improve measurably within 4–8 weeks of consistent use. Most cardiovascular studies use a minimum 12-week supplementation window.
How to Take It
Simple by design. Effective by science.
Two softgels. One meal. Every day. The VESIsorb® delivery system does the rest — no timing complexity, no stacking required.
What's Inside
What's inside,
and why it matters.
EPA (Eicosapentaenoic Acid)
A powerful natural anti-inflammatory agent and precursor to specialized pro-resolving mediators — lipoxins, resolvins, and protectins — that actively resolve inflammation rather than suppressing it. For runners and anyone with sore, achy joints, that means less stiffness and faster recovery between workouts.*
Molecularly Distilled Fish Oil
DHA (Docosahexaenoic Acid)
The dominant structural fatty acid in neuronal membranes and the primary component of neuronal phospholipids. Supports cognitive clarity, focus, and the membrane fluidity that declines measurably with age.*
Molecularly Distilled Fish Oil
Vitamin D3
Vitamin D3 (cholecalciferol) — the sunshine vitamin, the active form your body makes from sunlight. But most of us rarely get enough sun, making daily D3 essential. Fat-soluble and best absorbed alongside dietary fat and K2. Supports immune function, bone density, and muscle performance.*
Cholecalciferol
Vitamin K2 (MK-7)
Menaquinone-7 — the most bioavailable form of K2. Works synergistically with D3 to direct calcium into bones and away from arterial walls. An important safety co-factor for higher-dose D3 supplementation.*
Menaquinone-7 (MK-7)
VESIsorb® Delivery Matrix
A self-emulsifying colloidal delivery system that converts the omega-3 oil into nano-sized particles on contact with GI fluid — dramatically expanding surface area for absorption. Clinical data shows up to 6× greater blood levels versus standard softgels at an equivalent dose.*
Swiss Technology · EU
Dr. Devin Ryerson
Founder & Chief Curator · Est. 1999Why It Matters
Built by someone with
personal stakes in it.
Devin started Pure Prescriptions in 1999 after battling Hodgkin's Lymphoma and losing his father to leukemia. That experience made him the most stubborn kind of formulator — one who refuses to ship anything he wouldn't take himself.
Every ingredient here earned its place through clinical evidence, third-party testing, and that same personal lens — the five collagen types, the organic fruiting-body mushrooms, the co-factors. Nothing is decorative.
"Pure Prescriptions has always been more personal than corporate. Built by family. Still independent."
Our StoryYour Journey
What to expect
Omega-3 benefits accumulate with consistent daily use. Here’s the timeline.
Week 1–2
Inflammation Response
EPA begins modulating inflammatory pathways. Joints feel less stiff, post-exercise soreness diminishes, and some users notice improved mood and mental clarity.*
EPA Anti-Inflammatory
Week 4
Brain & Mood
DHA integration into neuronal membranes improves. Focus sharpens, mental fatigue reduces, and mood regulation benefits become noticeable for many users.*
DHA Cognitive Support
Week 8
Cardiovascular Markers
Triglyceride levels begin to improve with consistent use. Blood pressure support and improved circulation are common at this stage for those supplementing regularly.*
Heart Health Optimization
Week 12
Skin & Full Benefit
Radiant, hydrated skin. Stable mood. Healthy triglycerides. Reduced joint discomfort. At 12 weeks, the full spectrum of omega-3 benefits compounds into a measurably healthier baseline.*
Full Spectrum Benefit
Results are best with daily use · Most customers see full benefits by week 12
Results vary from person to person.
The Longevity Protocol
Where Science Meets
Longevity
The one compound that covers the most ground.
“If I had to strip my longevity protocol down to one product — one thing you put in your cart today and take every day for the next year — it’s the Omega-3. It’s the only compound that addresses systemic inflammation, cardiovascular health, brain structure, and longevity simultaneously.”
- 480mg DHA + 190mg EPA — above clinical study thresholds
- VESIsorb® delivery — self-emulsifying colloidal absorption
- Vitamin D3 + K2 included — synergistic fat-soluble co-factors
- Molecularly distilled — no heavy metals, no fishy aftertaste
Have Questions?
Everything you
need to know.
Honest answers — no marketing spin. If your question isn’t here, our team responds within one business day.
Premium Omega-3 Plus combines high-concentration EPA+DHA fish oil with three additional compounds most fish oils don’t include: Vitamin D3, Vitamin K2 (MK-7), and VESIsorb® delivery technology. VESIsorb creates a self-emulsifying colloidal dispersion that dramatically improves bioavailability — particularly relevant for fat-soluble nutrients. Standard fish oils are poorly absorbed unless taken with a high-fat meal. This one isn’t.
Omega-3s are fat-soluble and absorb best with dietary fat. Take 2 softgels with your largest meal of the day — typically lunch or dinner. VESIsorb technology improves absorption even on lighter meals, but food always helps. Never take on a completely empty stomach.
No. This formula uses molecularly distilled fish oil, which removes the oxidized lipids responsible for the fishy aftertaste and burping that low-quality fish oils are known for. We also include vitamin E as a natural antioxidant to protect against rancidity. Nearly all customers report zero aftertaste.
Vitamin D3 increases calcium absorption. Vitamin K2 (MK-7) directs that calcium into bones rather than arterial walls — where it can calcify and create cardiovascular risk. At higher D3 doses, K2 is considered an important co-factor by most practitioners. Both are fat-soluble and benefit from the same enhanced delivery system. Including them together in an omega-3 formula is clinically logical.
Joint comfort and skin texture often improve within 4–6 weeks. Cardiovascular marker improvements — including triglyceride levels and inflammatory markers — are measurable at 8–12 weeks with consistent daily use. Omega-3 Index levels (a clinical measure of omega-3 tissue saturation) improve detectably within 4–8 weeks.
Yes. Our fish oil undergoes molecular distillation for heavy metal removal and is independently tested for purity and potency. Certificate of Analysis available on request.
Doctor’s Protocol
How I’d build your
cardiovascular foundation.
“Omega-3s are the healthy inflammatory-response foundation. CoQ10 supports the mitochondria they help protect. Magnesium ensures the cofactors are there to complete ATP synthesis. Collagen closes the loop on structural repair. Each is powerful — together, they compound.*”
In Order of Priority
4 Products · 1 Protocol
Doctor's First Choice
Premium Omega-3 Plus
Start here. EPA+DHA via VESIsorb® with D3 and K2 — the foundation of a healthy inflammatory-response and cardiovascular-support protocol, delivering fat-soluble nutrients with clinical-grade absorption.*
Mitochondrial Energy
Bioactive Coenzyme Q10
EPA helps protect CoQ10 from oxidation at the mitochondrial membrane — the two compounds work synergistically for cellular energy support.*
ATP Cofactor · Recovery
Magnesium Glycinate
Magnesium and omega-3 support cardiovascular health through complementary mechanisms — vascular tone, healthy inflammatory balance, and endothelial function.*
Skin · Joints · Recovery
Perfect Collagen + Mushroom Blend
Omega-3's healthy inflammatory-response support complements the visible skin, joint, and recovery story of collagen — the two compounds support each other.*
Add the full protocol — earn $25 store credit on your next order.
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Orders Shipped
Years in Business
Founded
Owned & Operated
In the USA
