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The Pure Journal Devin's Take

Devin's Take

How to Build a Protocol That Actually Sticks

The gap between knowing what to take and actually taking it consistently is enormous. Here's how I've learned to close it — after 25 years of watching people fail at this.

Dr. Devin RyersonFounder, Pure Prescriptions
August 2026 7 min read

I’ve been in this industry for 25 years. I’ve talked to tens of thousands of customers. And the single most common reason a supplement protocol fails has nothing to do with the formula.

It’s consistency. Or the lack of it.

People spend real money on professional-grade supplements, do real research about what to take, build a thoughtful stack — and then take it for three weeks, fall off, restart, fall off again, and eventually decide the supplements “didn’t work.” The supplements didn’t fail. The system failed. And the system is fixable.

Here’s what I’ve learned — from my own routine and from watching thousands of other people try and fail at this — about how to build a protocol that actually lasts.

Start With Two. Not Ten.

The most common mistake I see is starting with everything at once. Someone reads about the Morning Method — collagen, greens, CoQ10, multivitamin — and decides to start all four on the same Monday. By Wednesday they’ve forgotten one. By Friday they’ve skipped two days. By the following Monday they’ve quietly shelved the whole thing.

The behavioral science on habit formation is unambiguous: adding multiple new behaviors simultaneously creates compounding friction. Each additional action is another opportunity to fail. Start with two products. Take them consistently for three weeks. Add the next one only after the first two are automatic.

My recommendation if you’re starting from scratch: collagen in your morning coffee, and magnesium before bed. That’s it. Those two have the widest impact across the most physiological systems — and they’re both dead simple to take. Master those first. Then build.

“A protocol you take 100% of the time for 60 days beats one you take 40% of the time for six months. Every time.”

Attach It to Something You Already Do

The behavioral term is habit stacking — pairing a new behavior with an existing automatic one. This is the most reliable technique I know for making supplements stick.

Morning

Coffee trigger.

If you drink coffee every morning — and most people do — that’s your anchor. Collagen goes in the coffee. You make the coffee, you add the collagen. It becomes one action instead of two.

Midday

Lunch trigger.

CoQ10 and your multivitamin go next to your lunch spot. You sit down to eat, you take them. The meal already provides the dietary fat that improves absorption. The timing handles itself.

Evening

Toothbrush trigger.

Magnesium lives next to your toothbrush. You brush your teeth, you take the magnesium. Most people brush before bed without thinking. Add one swallow of water and two capsules. Done.

The physical location matters too. Keep the supplements where you’ll use them, not in a cabinet you only open occasionally. If the magnesium is in the bathroom next to your toothbrush, you’ll take it. If it’s in the pantry behind the canned goods, you won’t.

Reduce the Friction to Zero

Friction is the enemy of consistency. Any step between you and the supplement is a potential dropout point.

I keep my morning supplements — collagen scoop, NewGreens packet — on the counter next to the coffee maker. My midday supplements are in a small dish on my desk. My evening supplements are in the bathroom. Everything is pre-organized, pre-positioned, and pre-counted. I never have to open a cabinet, find a bottle, unscrew a lid, and shake out a capsule while standing over the sink half-asleep.

If your current setup requires more than two seconds and one physical motion to execute, it’s too much friction. Simplify the setup. The supplements themselves are easy. Make the logistics easier than the supplements.

Don’t Chase Perfection

This one is underrated. People miss a day, decide they’ve “broken the streak,” and use it as justification to abandon the whole thing. The all-or-nothing thinking is the protocol killer.

Missing one day doesn’t matter. Missing three in a row starts to matter. Missing a week matters significantly — especially for things like creatine or magnesium, where consistent dosing is what builds the physiological effect.

The rule I use: never miss twice in a row. One missed day is an anomaly. Two missed days in a row is the beginning of a pattern. If you miss Monday, you take it Tuesday no matter what. That single rule has probably saved more supplement protocols than any optimization of timing or dosing.

“Never miss twice. One missed day is an anomaly. Two is a pattern.”

Give It 30 Days Before You Judge It

Most supplements that work don’t work immediately. Creatine takes 3–4 weeks to saturate muscle stores. Magnesium’s sleep benefits are typically noticeable within 2 weeks but peak around week 4–6. CoQ10’s mitochondrial effects accumulate over months. Collagen’s visible skin changes take 8–12 weeks of consistent use.

If you’re evaluating a supplement after two weeks and deciding it “doesn’t work,” you haven’t given it the time it needs to work. That’s not a failure of the product. That’s a failure of the evaluation timeline.

Commit to 30 days of genuine consistency before making any judgment. Keep a simple log — even just a note in your phone — of how you feel in the mornings, your energy at midday, your sleep quality at night. Not because the numbers matter, but because the process of noticing creates accountability.

The Only Protocol That Works Is the One You Actually Take

I’ve built protocols for professional athletes, physicians, and people who’ve never taken a supplement in their life. The variables are different. The fundamentals are identical.

Start small. Attach it to something automatic. Eliminate friction. Don’t quit after a missed day. Give it enough time to work.

The most sophisticated stack in the world is useless at 80% compliance. A simple, well-chosen two-product protocol at 100% compliance changes your health. Build the habit first. Optimize the formula second.

References

  1. 1.National Institutes of Health — Office of Dietary Supplements: Magnesium Fact Sheet for Health Professionals.

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