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5-MTHF 1 mg: A Bioactive Folate for Mood, Heart, and Nerve Health
Thorne’s 5-MTHF provides a 1-mg dose of L-5-Methyltetrahydrofolate, the most active, bioavailable form of folate. As an essential B vitamin, folate is crucial for a wide range of bodily processes, including neurotransmitter production, cardiovascular health, and healthy fetal development. However, a significant portion of the population has a genetic variation (MTHFR) that makes it difficult to convert standard folic acid into its active form. This formula bypasses that genetic hurdle, providing a tissue-ready folate for everyone.
How It Works: The Power of Methylation
5-MTHF is a primary “methyl donor,” which is a fundamental process that supports countless functions throughout the body.
Support for Mood and Brain Health
Healthy methylation is essential for the synthesis of key neurotransmitters like serotonin, dopamine, and norepinephrine. By providing a direct source of active folate, 5-MTHF supports a healthy mood, promotes a positive outlook, and supports overall cognitive function. It is a cornerstone nutrient for a well-balanced nervous system.
Promoting Cardiovascular Wellness
This active folate is also crucial for helping to maintain a healthy level of homocysteine, an amino acid that can be harmful to blood vessels at elevated levels. In addition, it plays a vital role in the formation of red blood cells and is particularly important for women of childbearing age to support healthy fetal brain and spinal cord development.
- ✅ Provides the active, methylated form of folate for superior bioavailability
- ✅ Ideal for individuals with an MTHFR gene variation
- ✅ Supports a positive mood and healthy neurotransmitter production
- ✅ Helps maintain healthy homocysteine levels for cardiovascular support
- ✅ Essential for healthy fetal development and red blood cell formation
Product Ingredients
Supplement Facts:
Suggested Use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Serving Size: One Capsule
Servings Per Container: 60
| Ingredient | Amount | %DV |
|---|---|---|
| Folate (1 mg as L-5-Methyltetrahydrofolate†) | 1.7 mg DFE | 425% |
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
*Daily Value (DV) not established.
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
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