Pure Encapsulations

MethylAssist

$64.00

SIZE: 90 Capsules

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The Promise

Targeted methylation support — activated B vitamins in one capsule*

A single vegetarian capsule that supplies active folate, methylated B12, benfotiamine and activated B6 to support methylation-related processes.*

Core ingredients and forms

Provides Metafolin® (L‑5‑MTHF) folate, methylcobalamin (B12), BenfoPure® benfotiamine and pyridoxal‑5‑phosphate (active B6).

Potent, defined amounts

Each capsule contains 1,000 mcg L‑5‑MTHF, 1,000 mcg methylcobalamin, 75 mg benfotiamine and 16 mg pyridoxal‑5‑phosphate.

Clean, hypoallergenic delivery

Vegetarian capsule made with hypoallergenic plant fiber (cellulose) and no common allergens listed.

Single daily dosing

Suggested use is one capsule daily with a meal or as directed by a health professional.

Why It Works

Why this formulation matters — forms chosen for direct usability

Active vitamin forms and trademarked ingredients are included so the body can use them without extra enzymatic activation steps.

01

L‑5‑MTHF vs folic acid

Folate is supplied as Metafolin® L‑5‑MTHF, the naturally occurring, directly usable form of folate that bypasses several activation steps.

02

Methylcobalamin source

Vitamin B12 is provided as methylcobalamin derived from corn dextrose fermentation.

03

Activated B6 included

Pyridoxal‑5‑phosphate is the activated form of vitamin B6 used in enzymatic reactions that metabolize homocysteine.

04

Lipid‑soluble thiamine analogue

BenfoPure® benfotiamine is the lipid‑soluble form of thiamine included at 75 mg per capsule.

Reviews

Customer Reviews

Your Journey

How to use it — simple daily integration

Take one vegetarian capsule daily with a meal; consult a health professional for personalized guidance.

Serving

Take one capsule daily

Follow the recommended single‑capsule serving; do not exceed without professional advice.

When to take

With a meal

Take the capsule with food as recommended for this formulation.

Clinical precautions

Consult if pregnant or on chemotherapy

If pregnant or lactating consult your physician before use; folate can interact with some chemotherapeutic drugs.

Dietary fit and form

Vegetarian and hypoallergenic

Capsule uses hypoallergenic plant cellulose and is suitable for vegetarian diets.

Product education

methyl Assist Information, Uses, Dosage & Recommendations 

Uses For MethylAssist

Cellular Function: Methylation involves the transfer of a methyl group (CH3) from one molecule to another. This methyl group acts as a signal throughout the body, regulating genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism. Activated B vitamins provide methyl groups to support healthy methylation.*

Neuronal Health: Optimal levels of B vitamins have been associated with neurological and psychological health. Research suggests that folate, vitamin B12, vitamin B6 and benfotiamine help maintain healthy nervous system function and comfort. In a randomized controlled study, benfotiamine supported healthy nerve conduction velocity and nerve comfort. In another trial, a combination of L-methylfolate, methycobalamin and pyridoxal-5-phosphate promoted healthy epidermal nerve fiber density and nerve comfort.*

Cardiovascular Health: B vitamins offer cardiovascular support by promoting healthy endothelial function and methionine metabolism. Research suggests that folate and benfotiamine enhance healthy endothelial function, vascular dilation and nitric oxide status. In addition, clinical studies show that folate, vitamin B12, and vitamin B6 are vital in the metabolism of homocysteine. Vitamin B12 and folate are required by the enzyme that converts homocysteine back to methionine. Folate is provided in this formula as Metafolin®, the naturally occurring, universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. Vitamin B6 is required in each of the two enzymatic reactions that convert homocysteine to cysteine.*

MethylAssist

What Is The Source of Ingredients In MethylAssist?

Folate (as Metafolin®, L-5-MTHF), BenfoPure® benfotiamine and pyridoxal 5’ phosphate are synthetic. Vitamin B12 (methylcobalamin) is derived from corn dextrose fermentation. Hypoallergenic plant fiber is derived from pine cellulose.

MethylAssist Dosage Recommendations

Pure Encapsulations® recommends 1 capsule daily, with a meal, or as directed by a health professional.
Are There Any Potential Side Effects Or

Does MethylAssist Have Precautions?

If pregnant or lactating, consult your physician before taking this product. At this time, there are no known side effects or precautions. Consult your physician for more information.

Are There Any Potential Drug Interactions?

Folate may adversely interact with chemotherapeutic drugs. Consult your physician for more information.

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.

BenfoPure® is a registered trademark of Hamari Chemicals USA, Inc.

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: 1 capsule daily, with a meal, or as directed by a health professional.
each vegetarian capsule contains:
Ingredients AMT %DV
folate (as Metafolin®, L-5-MTHF) 1,000 mcg -
vitamin B12 (as methylcobalamin) 1,000 mcg -
BenfoPure® benfotiamine 75 mg -
pyridoxal 5' phosphate (activated B6) 16 mg -
Other Ingredients: hypo-allergenic plant fiber (cellulose), vegetarian capsule (cellulose, water)
(-) There is no %DV or the manufacturer has not provided this data.