Thorne Methyl-Guard - A supplement with active B vitamins and betaine for methylation and homocysteine support.
Thorne Methyl-Guard - A supplement with active B vitamins and betaine for methylation and homocysteine support.
Thorne Methyl-Guard - A supplement with active B vitamins and betaine for methylation and homocysteine support.

Thorne Research

Methyl-Guard

$56.00

SIZE: 180 Capsules

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SKU: T87037 Categories: , , Tags: , , Product Brand:

The Promise

Product identity & formulation Active B‑vitamin and betaine formula

Methyl‑Guard by Thorne Research — vegetarian capsule delivering tissue‑ready folate, B6, B12, and betaine.

Brand and product

Thorne Research Methyl‑Guard; foundational methylation support formula in a hypromellose (cellulose‑derived) capsule.*

Principal ingredients & forms

L‑5‑Methyltetrahydrofolate (5‑MTHF, glucosamine salt), Pyridoxal‑5′‑Phosphate (P‑5‑P), Methylcobalamin, Betaine (trimethylglycine).

Key amounts per labelled serving

Serving = 3 capsules: Vitamin B6 (P‑5‑P) 20.4 mg; Folate 1.2 mg as L‑5‑MTHF (2 mg DFE); Vitamin B12 (methylcobalamin) 1.2 mg; Betaine Anhydrous 1.8 g.

Formulation & quality notes

Vegetarian capsule with silicon dioxide, calcium citrate, calcium laurate; 60 servings per container (serving size = 3 capsules).

Why It Works

Why these ingredients Active, tissue‑ready cofactors and an alternative methyl donor

Specific forms and amounts support methylation biochemistry and offer an alternate betaine pathway.*

01

Active folate form

Provides 1.2 mg L‑5‑MTHF (glucosamine salt) — the reduced, methylated folate form listed on the label (2 mg DFE).

02

Tissue‑ready B6

Contains 20.4 mg pyridoxal‑5′‑phosphate (P‑5‑P), the active coenzyme form of vitamin B6 shown on the Supplement Facts.

03

Methylcobalamin B12

Delivers 1.2 mg methylcobalamin (labelled amount), the methylated form of vitamin B12.

04

High‑dose betaine

Includes 1.8 g betaine anhydrous (trimethylglycine) per serving as an additional methyl donor pathway.

Reviews

Customer Reviews

Your Journey

How to use & precautions Labelled directions, serving size, storage, and safety notes

Follow labeled dosing and heed warnings and interactions.

Serving

Dosage and frequency

Take 3 capsules two times daily or as recommended by your health‑care practitioner. Serving size = three capsules; 60 servings/container.

Format & storage

Capsule format

Hypromellose (cellulose‑derived) vegetarian capsules; store per container instructions (keep in original container).

Allergy & pregnancy

Contraindication and pregnancy advisory

Contraindicated in individuals with hypersensitivity to any ingredients. If pregnant, consult your health‑care practitioner before use.

Interactions

Methotrexate interaction note

5‑MTHF supplementation is not recommended concurrently with methotrexate cancer therapy because it can interfere with anti‑neoplastic activity; 5‑MTHF has not been shown to interfere with methotrexate's anti‑inflammatory activity—individuals taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Product education

Methyl-Guard: A Foundational Formula for Healthy Methylation

Thorne’s Methyl-Guard is a foundational supplement designed to support the body’s crucial methylation pathway. This synergistic formula provides the active, tissue-ready forms of folate, vitamin B6, and vitamin B12, along with betaine (trimethylglycine). Proper methylation is essential for a wide range of bodily functions, from cardiovascular health and detoxification to neurotransmitter production. Methyl-Guard is a trusted choice for individuals seeking to support healthy homocysteine levels and promote overall wellness.*

How It Works: The Power of Active B Vitamins and Betaine

This formula provides the key nutrients that act as “methyl donors,” which are required to fuel the methylation cycle.

Support for Cardiovascular and Neurological Health
Methyl-Guard is particularly effective at supporting the body’s process of converting homocysteine—a damaging amino acid when elevated—into the beneficial amino acid methionine. The active forms of Folate (5-MTHF), Vitamin B12 (methylcobalamin), and Vitamin B6 (P-5-P) are essential cofactors for this process. In addition, Betaine provides an alternate pathway for homocysteine metabolism, offering comprehensive support for cardiovascular health.*

Promoting a Healthy Mood and Detoxification
A balanced methylation cycle is also vital for the synthesis of key neurotransmitters like serotonin and dopamine, making it fundamental to a positive mood. Furthermore, methylation is a key step in the liver’s detoxification pathways. By providing these essential nutrients, Methyl-Guard supports the body’s ability to process and eliminate toxins, making it a cornerstone formula for foundational health.*

  • Supports the body’s natural methylation cycle*
  • Helps maintain healthy homocysteine levels for cardiovascular wellness*
  • Contains the active, bioavailable forms of folate, B6, and B12*
  • Supports a positive mood and healthy neurotransmitter production*
  • Ideal for individuals needing methylation support, such as those with MTHFR variants*

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner.
Serving Size: Three Capsules
Servings Per Container: 60
Ingredient Amount %DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate) from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt† 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g **
Other ingredients: Hypromellose (derived from cellulose) capsule, Silicon Dioxide, Calcium Citrate, Calcium Laurate.
**Daily Value (DV) not established.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

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