Thorne Methyl-Guard Plus (90 Capsules) - active B vitamin complex for methylation and homocysteine support.
Thorne Methyl-Guard Plus (90 Capsules) - active B vitamin complex for methylation and homocysteine support.
Thorne Methyl-Guard Plus (90 Capsules) - active B vitamin complex for methylation and homocysteine support.

Thorne Research

Methyl-Guard Plus

$62.00

SIZE: 90 Capsules

*Free shipping applies to orders shipped within the Lower 48 States.


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SKU: T89017 Categories: , , Tags: , , Product Brand:

The Promise

What this product is High‑potency, active‑form methylation support*

A concentrated blend of bioactive B vitamins plus betaine formulated to support the methylation pathway.*

Identity

Methyl‑Guard Plus — Thorne Research advanced methylation supplement in oral capsule form.

Principal ingredients & forms

Active B vitamins: L‑5‑MTHF (folate), methylcobalamin (B12), pyridoxal‑5‑phosphate (B6), riboflavin‑5'‑phosphate (B2); plus Betaine Anhydrous (TMG).

Formulation & potency

High‑potency single‑bottle formula delivering tissue‑ready B vitamins and 1.8 g betaine per full serving.

Delivery & quality facts

Vegetable‑derived hypromellose capsule; includes calcium citrate and calcium laurate; manufactured by Thorne Research.

Why It Works

Why these ingredients matter Specific active forms and measured doses for direct use by the body

Key nutrients are provided in their bioactive forms and at defined amounts to supply methyl groups and related cofactors.

01

Measured riboflavin (B2)

Riboflavin as riboflavin‑5'‑phosphate — 90 mg per serving (listed on label).

02

Active vitamin B6 (P‑5‑P)

Pyridoxal‑5‑phosphate (P‑5‑P) — 45 mg per serving (label amount).

03

L‑5‑MTHF folate and methylcobalamin

L‑5‑MTHF provided as 3 mg L‑5‑MTHF (5 mg DFE) and vitamin B12 as methylcobalamin 3 mg per serving (label amounts).

04

High‑dose betaine (TMG)

Betaine Anhydrous (trimethylglycine) — 1.8 g per serving to provide an additional methylation pathway (label amount).

Reviews

Customer Reviews

Your Journey

How to use this product Serving, timing, format, and safety notes from the label

Follow label directions or your health‑care practitioner's guidance; observe precautions and interactions noted on the product label.

Serving

Suggested use and serving size

Take 1–3 capsules daily or as recommended by your health‑care practitioner. Serving size on label: three capsules; 30 servings per container.

Format & storage

Capsule format and excipients

Vegetable hypromellose capsule with calcium citrate and calcium laurate; store per package instructions (keep container closed).

Warnings

Allergy, pregnancy, and contraindications

Contraindicated with known hypersensitivity to any ingredient. If pregnant, consult your health‑care practitioner before use.

Drug interaction note

Methotrexate interaction guidance

5‑MTHF supplementation is not recommended concurrently with methotrexate cancer therapy; separate guidance given for methotrexate used in psoriasis or rheumatoid arthritis on the label.

Product education

Methyl-Guard Plus: Advanced Support for Healthy Methylation*

Thorne’s Methyl-Guard Plus delivers a powerful, targeted blend of essential nutrients in their most active, bioavailable forms to support the body’s critical methylation pathway. Methylation is a fundamental biochemical process that impacts nearly every cell and organ, influencing everything from cardiovascular and neurological health to detoxification and mood regulation. This formula provides a high-potency combination of B vitamins and betaine to promote healthy homocysteine levels, support neurotransmitter production, and optimize overall wellness for individuals needing more robust methylation support.*

How It Works: The Power of Active, Tissue-Ready Nutrients

Many individuals have genetic variations, like those in the MTHFR gene, that can make it difficult to convert standard B vitamins into their active forms. Methyl-Guard Plus bypasses these potential roadblocks by providing nutrients that are ready for your body to use immediately.

Bioactive B Vitamins
This formula features the active forms of folate (L-5-MTHF), vitamin B12 (methylcobalamin), vitamin B6 (P-5-P), and vitamin B2 (riboflavin 5′-phosphate). These B vitamins are crucial “methyl donors” that facilitate the conversion of the potentially harmful amino acid homocysteine into the beneficial amino acid methionine. Maintaining a healthy homocysteine level is vital for cardiovascular health, while proper B vitamin status is essential for producing the neurotransmitters that regulate mood, such as serotonin and dopamine.

Betaine (TMG) for Added Support
To provide even more comprehensive support, Methyl-Guard Plus includes a significant amount of Betaine Anhydrous, also known as TMG (trimethylglycine). Betaine offers an additional pathway for homocysteine metabolism, particularly in the liver, which supports detoxification processes. It also protects against fat accumulation in the liver and provides further support for cardiovascular health. This synergistic formula ensures a multi-faceted approach to maintaining a balanced and efficient methylation cycle.*

  • Promotes healthy methylation to support hundreds of bodily processes*
  • Helps maintain healthy homocysteine levels for cardiovascular wellness*
  • Contains the most bioactive forms of B2, B6, B12, and folate
  • Ideal for individuals with MTHFR gene variants needing methylation support*
  • Supports positive mood, detoxification, and nerve health*

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take 1-3 capsules daily or as recommended by your health-care practitioner.
Serving Size: Three Capsules
Servings Per Container: 30
Ingredient Amount %DV
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg 6,923%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg 2,647%
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE 1,250%
Vitamin B12 (as Methylcobalamin) 3 mg 125,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g **
Other ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.
*Daily Value (DV) not established.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

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