Life Extension

High Potency Optimized Folate 8500mcg

$18.00

SIZE: 30 Tablets

*Free shipping applies to orders shipped within the Lower 48 States.

Free shipping on orders over $99.

The Promise

Product identity & core formulation High‑potency active folate in a single vegetarian tablet

Directly delivers the bioactive folate form to bypass common conversion limits.

Active ingredient

(6S)-5‑Methyltetrahydrofolate, calcium salt — 8500 mcg DFE per tablet.

Form & delivery

One vegetarian tablet per serving — oral tablet taken with food.

Quality & extras

Non‑GMO; excipients include microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.

Packaging & safety

Tamper-evident outer seal — do not purchase if seal is broken or damaged.

Why It Works

Distinct formulation facts Specific amounts, form, and safety considerations shown on the label

Concrete, label-backed details you can rely on when comparing products.

01

Ultra‑high dose

Provides 8500 mcg DFE of 5‑MTHF per tablet (labelled amount).

02

Bioactive folate form

Supplies 5‑MTHF (metabolically active folate) rather than folic acid, avoiding required enzymatic conversion.

03

Vegetarian tablet excipients

Includes binding and disintegrant agents (microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium) for tablet integrity and release.

04

B12 caution noted

Label cautions that high‑dose folate may mask signs of vitamin B12 deficiency — consult your healthcare provider if at risk.

Reviews

Customer Reviews

Your Journey

How to use & safety Clear, label‑specified directions and warnings

Follow these labeled instructions and precautions for everyday use.

Serving

Suggested use

Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Dose limits

Do not exceed

Do not exceed recommended dose as stated on the label.

Storage & handling

Keep and inspect

Keep out of reach of children; do not purchase if outer seal is broken or damaged.

Medical considerations

Consult your provider

Consult a physician if undergoing treatment for a medical condition, pregnant or lactating, or if at risk of vitamin B12 deficiency.

Product education

High Potency Optimized Folate

Heart & brain health, homocysteine support, strong dose*

Our High Potency Optimized Folate is a cardiovascular health supplement that also supports cognitive health and more with 8500 mcg of metabolically active 5-MTHF.*

  • Ultra-potent 8500 mcg dose of active folate (5-MTHF)
  • Supports cardiovascular health & cognitive function*
  • Helps maintain already-healthy homocysteine levels*

What is High Potency Optimized Folate?

Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with both cardiovascular and cognitive health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.*

High Potency Optimized Folate Benefits*

  • Super high-potency dose of bioavailable 5-MTHF folate*
  • Supports both cardiovascular & cognitive health*
  • Helps maintain already-healthy homocysteine levels*
  • 5-MTHF folate overcomes the enzyme inefficiency roadblock

Why Choose 5-MTHF?

Folic acid is the most common form of folate supplements. Once ingested, your body is supposed to convert folic acid into 5-methyltetrahydrofolate (5-MTHF). However, many people lack sufficient activity of the enzyme required for this process. By taking 5-MTHF directly, you bypass this bottleneck and ensure your body gets the active form it needs.

5-MTHF, Homocysteine & Heart + Brain Health

Folate helps support already-healthy homocysteine levels—a key marker of cardiovascular and cognitive wellness. Studies show that 5-MTHF offers greater bioavailability than folic acid, especially for those with limited enzyme activity. It’s also associated with better cognitive support in aging individuals.*

How to Maximize Results

This high-potency formula provides 8500 mcg DFE of 5-MTHF. For additional support, consider pairing it with methylcobalamin (vitamin B12), vitamin B6, and riboflavin for synergistic benefits.*

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.
Serving Size: 1 vegetarian tablet
Ingredient Amount %DV
Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] 8500 mcg° **
Other ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.
Non‑GMO
Caution: Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs.
Warnings: KEEP OUT OF REACH OF CHILDREN DO NOT EXCEED RECOMMENDED DOSE Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.