Folate 400

Pure Encapsulations

Folate 400

$22.00

SIZE: 90 Capsules

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SKU: FOL49 Categories: , , , Product Brand:

The Promise

Bioactive Folate — ready-to-use L-5-MTHF Metafolin® form for direct use

Provides folate as Metafolin® (L-5-methyltetrahydrofolate), the active, naturally occurring folate metabolite.

Single, active folate form

Each capsule supplies 400 mcg folate as Metafolin® (L-5-MTHF), the chemically identical active folate metabolite.

Higher bioavailability*

Contains the naturally occurring form L-5-MTHF that accumulates in red blood cells more than equimolar folic acid in clinical comparison.

Hypo-allergenic capsule filler

Vegetable capsule completed with hypo-allergenic plant fiber derived from pine cellulose.

Clear dosing guidance

Suggested use is 1–2 capsules per day with a meal, supplied as a 90-capsule bottle.

Why It Works

Why this folate matters Active form and metabolic advantage

L-5-MTHF bypasses multiple activation steps and is directly usable in methylation reactions and nucleic acid synthesis.

01

Bypasses enzymatic activation

Metafolin® is already the active 5-methyltetrahydrofolate so it does not require the enzymatic conversions needed by folic acid.

02

Direct substrate for methylation

Provides methyl groups usable in essential methylation reactions in blood cells, neurons, and vascular tissues.

03

Preferable with genetic variations

Because it is universally metabolized, it provides active folate regardless of common genetic differences in folic acid activation.

04

Clinically demonstrated RBC accumulation*

In a randomized study of women of childbearing age, 5-MTHF produced greater red blood cell 5-MTHF accumulation than an equimolar folic acid dose.

Reviews

Customer Reviews

Your Journey

How to use it Simple daily capsule routine

Take 1–2 vegetable capsules per day with a meal; consult your physician if pregnant, lactating, or receiving medical treatment.

Serving

Daily dose

Take one capsule daily for 400 mcg folate or two capsules for 800 mcg, with a meal.

Timing

When to take it

Take with a meal to support consistent daily use and reduce the chance of stomach upset.

Format

Vegetable capsules

Delivered in a vegetable capsule using hypo-allergenic plant fiber as filler.

Dietary fit

Suitable for many diets

Contains no common allergens in the capsule filler; check other product details if you have specific dietary restrictions.

Product education

Suggested Use: 1-2 capsules per day, with a meal.

Folate 400 – Folate 400 by Pure Encapsulations provides the most highly absorbed form of folate available, Metafolin L-5MTHF. Folate is important for brain and nervous system development and functioning. Folate is also vital for pregnant women as it particularly important for fetal development. Those whose who suffer from malabsorption, or intestinal issues may benefit from supplementing.

What Is It?

Folate is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations.*

Uses For Folate 400

Cellular Health: An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. Metafolin is a naturally occurring universally metabolized and active form of folate, L-5-MTHF. As such, it can be directly used in a diverse array of essential methylation reactions. Additionally, clinical evidence indicates that the bioavailability of Metafolin is superior to folic acid. In a double-blind, randomized, placebo-controlled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid. Adequate folate status is critical for nucleic acid synthesis and neurotransmitter synthesis. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues.*

What Is The Source?

Metafolin®, L-5-methyltetrahydrofolate (L-5-MTHF) is synthetic. Hypo-allergenic plant fiber is derived from pine cellulose. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany

Recommendations

Pure Encapsulations recommends 1-2 capsules per day, with a meal.

Are There Any Potential Side Effects Or Precautions?

At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.

Are There Any Potential Drug Interactions?

Folic acid may adversely interact with chemotherapeutic drugs. Consult your physician for more information.

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: 1-2 capsules per day, with a meal.
each vegetable capsule contains
Ingredients AMT %DV
folate (as Metafolin®, L-5-MTHF) 400 mcg. -
Other Ingredients: (hypo-allergenic plant fiber added to complete capsule volume)
(-) There is no %DV or the manufacturer has not provided this data.

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