Metagenics AdvaClear(R) -- detoxification support, liver health.
Metagenics AdvaClear(R) -- detoxification support, liver health. - Back

Metagenics

AdvaClear®

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The Promise

Product identity & core formulation Targeted methylation and liver-support blend in a vegetarian capsule*

AdvaClear® combines methylated B‑vitamins, botanical extracts and sulfur donors to support daily detoxification pathways.*

Identity

AdvaClear® by Metagenics, 42‑count bottle (21 servings).

Principal ingredients & forms

Includes methylcobalamin (vitamin B12 as methylcobalamin 33.4 mcg) and methylated folate (calcium L‑5‑methyltetrahydrofolate, 445 mcg DFE).

Complementary actives

Botanicals and sulfur donors: artichoke leaf extract 167 mg, N‑acetyl‑L‑cysteine 67 mg, silymarin (milk thistle) 50 mg, pomegranate extract 87.5 mg (standardized to 45.8 mg GAE).

Delivery & quality facts

Vegetarian capsule (hydroxypropylmethylcellulose); other ingredient forms noted (selenium as selenomethionine; zinc as zinc citrate).

Why It Works

Why these ingredients matter Specific forms, amounts, and standardizations chosen for targeted biochemical support*

Formulation details reflect explicit ingredient forms, standardized extracts, and measurable potencies.

01

Methylated B‑vitamins

Folate provided as calcium L‑5‑methyl‑THF (445 mcg DFE) and B12 as methylcobalamin (33.4 mcg), i.e., methylated cofactor forms.

02

Standardized botanical extracts

Pomegranate extract quantified to 45.8 mg gallic acid equivalents (87.5 mg extract); green tea extract standardized to 60% catechins (33.6 mg) and 40% EGCG (22.4 mg).

03

Sulfur and thiol support*

Includes N‑acetyl‑L‑cysteine 67 mg and sodium sulfate 100 mg—sulfur‑containing ingredients used in conjugation pathways.

04

Liver‑support phytochemicals*

Artichoke leaf extract (167 mg, contains cynarin and chlorogenic acid) and silymarin (50 mg) present for phytochemical support of hepatic detoxification processes.*

Reviews

Customer Reviews

Your Journey

How to use AdvaClear® Clear, label‑based directions, precautions, and practical notes

Follow serving directions and labeled precautions; consult a practitioner when indicated.

Serving

Dosage

Take two capsules once daily or as directed by your healthcare practitioner. Serving size: 2 capsules; 21 servings per container.

Format & administration

Capsule form

Vegetarian hydroxypropylmethylcellulose capsule. Swallow whole with water.

Precautions

Pregnancy & medication

Excess vitamin A intake may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg preformed vitamin A per day. If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.

Storage & safety

Keep out of reach

Keep out of the reach of children. Contains specified minerals and botanical extracts; see supplement facts for full ingredient list.

Product education

AdvaClear® by Metagenics

AdvaClear® promotes daily detoxification for optimal health and vitality. This supplement provides methylated B12 and folate, enhancing the activities of several liver detoxification enzymes. It supports both Phase I and Phase II detoxification pathways, making it an excellent choice for those looking to maintain their overall health.*

Key Benefits

  • Promotes daily detoxification*
  • Enhances liver detoxification enzymes
  • Supports methylation processes*

How It Works / Key Ingredients

AdvaClear® contains a blend of vitamins, minerals, and herbal extracts that work synergistically to support the body’s natural detoxification processes. Key ingredients include methylated forms of B12 and folate, as well as artichoke leaf extract and N-acetyl-L-cysteine.*

Supplement record

Review serving details and ingredients for this product.

Supplement Facts
Suggested Use: Directions: Take two capsules once daily or as directed by your healthcare practitioner.
Serving Size: 2 capsules
Servings Per Container: 21
INGREDIENTSAMT%DV
Vitamin A (from mixed carotenoids††and retinyl palmitate)750 mcg83% 
Vitamin C (as ascorbic acid)133 mg 148% 
Vitamin D (as cholecalciferol)33 IU 4% 
Vitamin E (as d-alpha tocopheryl succinate)44.6 mg297% 
Thiamin (as thiamin mononitrate)10 mg 833% 
Riboflavin5 mg 385% 
Niacin (as niacinamide and niacin)23.3 mg  146% 
Vitamin B6 (as pyridoxine HCI)16.66 mg980% 
Folate (as calcium L-5-methyl-tetrahydrofolate††††)445 mcg DFE111% 
Vitamin B12 (as methylcobalamin)33.4 mcg 1,392% 
Biotin66 mcg 220% 
Pantothenic Acid (as d-calcium pantothenate)33.3 mg 666% 
Zinc (as zinc citrate)6.5 mg 59% 
Selenium (as selenomethionine)50 mcg 91% 
Copper (as copper citrate)0.66 mg 73% 
Manganese (as manganese citrate)1.66 mg 72% 
Molybdenum (as molybdenum aspartate)66 mcg 147% 
Sodium (as sodium sulfate)40 mcg 2% 
Artichoke (Cynara scolymus) Leaf Extract (containing cynarin and chlorogenic acid)167 mg †
Watercress (Nasturtium officinale) Aerial Parts 4:1 Extract133 mg †
Taurine117 mg †
Sodium Sulfate100 mg †
Pomegranate (Punica granatumL.) Whole Fruit Extract [standardized to 45.8 mg gallic acid equivalent (GAE)]87.5mg †
N-Acetyl-L-Cysteine67 mg †
Decaffeinated‡ Green Tea (Camellia sinensis) Leaf Extract [standardized to 60% (33.6 mg) catechins and 40% (22.4 mg) epigallocatechin gallate (EGCG)]56 mg †
Silymarin (from milk thistle seed extract,Silybum marianum)50 mg †
(†) Daily Value not established
Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica.
Warnings/Caution: Excess vitamin A intake may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day. If pregnant or nursing, or taking medications, consult your healthcare practitioner before use. Keep out of the reach of children.

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