Thorne Research

5-MTHF 5mg

$68.00

SIZE: 60 Capsules

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The Promise

Identity & Composition High‑potency, bioactive folate in capsule form

L-5-Methyltetrahydrofolate (5-MTHF) delivered as a 5 mg capsule; 60 servings per container.

Active ingredient

Provides 5 mg L-5-Methyltetrahydrofolate (5-MTHF), the methylated, bioactive form of folate.

Potency & label basis

Each capsule supplies 5 mg folate (listed as 8.3 mg 5-MTHF; 2,075% Daily Value as 8.3 mg DFE).

Formulation & delivery

Vegetarian hypromellose capsule with microcrystalline cellulose, leucine, and silicon dioxide.

Packaging & servings

60 capsules per container; serving size one capsule.

Why It Works

Distinct formulation facts Concrete details you can act on

Specific ingredient forms, amounts, and formulation notes that differentiate this product.

01

Methylated folate form

Uses L-5-Methyltetrahydrofolate, the active methylated form rather than folic acid.

02

High numeric dose

Delivers a 5 mg labeled dose (8.3 mg 5-MTHF; 2,075% DV as 8.3 mg DFE) suitable for increased needs.

03

Capsule excipients

Contains microcrystalline cellulose, hypromellose capsule shell, leucine, and silicon dioxide.

04

Medication interaction note

Not recommended concurrently with methotrexate cancer therapy because it can interfere with methotrexate's anti‑neoplastic activity.

Reviews

Customer Reviews

Your Journey

How to Use & Safety Clear directions, warnings, and practical considerations

Follow labeled serving directions and heed allergy, pregnancy, and interaction warnings.

Serving

Suggested use

Take 1 capsule one to two times daily or as recommended by your health‑care practitioner.

Packaging details

Servings per container

60 capsules — based on one capsule daily, supply lasts ~60 days (adjust if taking two daily).

Warnings

Allergy and pregnancy guidance

ALLERGY WARNING: Contraindicated with history of hypersensitivity to any ingredients. If pregnant, consult your health‑care practitioner before using.

Drug interaction

Methotrexate guidance

5-MTHF supplementation is not recommended concurrently with methotrexate cancer therapy; does not appear to interfere with methotrexate's anti‑inflammatory activity for psoriasis or rheumatoid arthritis.

Product education

5-MTHF 5 mg: A High-Potency, Bioactive Folate for Mood, Heart, and Nerve Health

Thorne’s 5-MTHF provides a high-potency, 5-mg dose of L-5-Methyltetrahydrofolate, the most active, bioavailable form of folate. As an essential B vitamin, folate is crucial for a wide range of bodily processes. These include neurotransmitter production, cardiovascular health, and healthy fetal development. However, many individuals have a genetic variation (MTHFR) that makes it difficult to convert standard folic acid into its active form. This formula bypasses that genetic hurdle, providing a tissue-ready folate for those with increased nutritional needs.*

How It Works: The Power of Methylation

5-MTHF is a primary “methyl donor,” which is a fundamental process that supports countless functions throughout the body.*

Support for Mood and Brain Health
Healthy methylation is essential for the synthesis of key neurotransmitters like serotonin, dopamine, and norepinephrine. By providing a direct source of active folate, 5-MTHF supports a healthy mood and a positive outlook. It is also a cornerstone nutrient for a well-balanced nervous system and overall cognitive function.*

Promoting Cardiovascular Wellness
This active folate is also crucial for helping to maintain a healthy level of homocysteine, an amino acid that can be harmful to blood vessels at elevated levels. In addition, it plays a vital role in the formation of red blood cells. It is also particularly important for women of childbearing age to support healthy fetal brain and spinal cord development.*

  • Provides a high-potency 5mg dose of the active, methylated form of folate
  • Ideal for individuals with an MTHFR gene variation
  • Supports a positive mood and healthy neurotransmitter production*
  • Helps maintain healthy homocysteine levels for cardiovascular support*
  • Essential for healthy fetal development and red blood cell formation

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Serving Size: One Capsule
Servings Per Container: 60
Ingredient Amount %DV
Folate (5 mg as L-5-Methyltetrahydrofolate†) 8.3 mg DFE 2,075%
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
*Daily Value (DV) not established.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.