5-MTHF 1 mg: A Bioactive Folate for Mood, Heart, and Nerve Health
Thorne’s 5-MTHF provides a 1-mg dose of L-5-Methyltetrahydrofolate, the most active, bioavailable form of folate. As an essential B vitamin, folate is crucial for a wide range of bodily processes, including neurotransmitter production, cardiovascular health, and healthy fetal development. However, a significant portion of the population has a genetic variation (MTHFR) that makes it difficult to convert standard folic acid into its active form. This formula bypasses that genetic hurdle, providing a tissue-ready folate for everyone.*
How It Works: The Power of Methylation
5-MTHF is a primary “methyl donor,” which is a fundamental process that supports countless functions throughout the body.*
Support for Mood and Brain Health
Healthy methylation is essential for the synthesis of key neurotransmitters like serotonin, dopamine, and norepinephrine. By providing a direct source of active folate, 5-MTHF supports a healthy mood, promotes a positive outlook, and supports overall cognitive function. It is a cornerstone nutrient for a well-balanced nervous system.*
Promoting Cardiovascular Wellness
This active folate is also crucial for helping to maintain a healthy level of homocysteine, an amino acid that can be harmful to blood vessels at elevated levels. In addition, it plays a vital role in the formation of red blood cells and is particularly important for women of childbearing age to support healthy fetal brain and spinal cord development.*
- Provides the active, methylated form of folate for superior bioavailability*
- Ideal for individuals with an MTHFR gene variation
- Supports a positive mood and healthy neurotransmitter production*
- Helps maintain healthy homocysteine levels for cardiovascular support*
- Essential for healthy fetal development and red blood cell formation








