Thorne Research

5-MTHF 1mg

$24.00

SIZE: 60 Capsules

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The Promise

Product Identity and Quality Active, bioavailable L‑5‑MTHF in a clean capsule*

Thorne Research 5‑MTHF delivers methylated folate in a vegetarian capsule with minimal excipients.

Identity

Contains L‑5‑Methyltetrahydrofolate (5‑MTHF), the active methylated form of folate.

Dose & Form

Each capsule provides 1 mg 5‑MTHF (listed as 1.7 mg DFE, 425% DV).

Formulation

Vegetarian hypromellose capsule with microcrystalline cellulose, leucine, and silicon dioxide.

Quality Notes

Manufactured by Thorne Research; labeled servings per container: 60.

Why It Works

Why This Formulation Concrete formulation details and physiological roles

Key formulation facts and the role of 5‑MTHF in methylation and folate-dependent processes.

01

Active, tissue‑ready form

Provides L‑5‑MTHF, the bioactive folate that bypasses conversion steps required for folic acid.

02

Specific amount

Each capsule supplies 1 mg of 5‑MTHF (amount shown as 1.7 mg DFE, 425% DV).

03

Methyl donor role

5‑MTHF functions as a methyl donor in methylation pathways involved in neurotransmitter synthesis and red blood cell formation.

04

Genetic consideration

Formulated for individuals with MTHFR variations who have reduced ability to convert folic acid to active folate.

Reviews

Customer Reviews

Your Journey

Usage, Safety, and Practicals Clear directions, contraindications, and practitioner guidance

How to take it, storage and key warnings drawn from the label.

Suggested Use

Serving instructions

Take 1 capsule one to three times daily or as recommended by your health‑care practitioner.

Format & Supply

Capsule format

Vegetarian hypromellose capsule; 60 servings per bottle.

Contraindications

Allergy and pregnancy guidance

Contraindicated in individuals with hypersensitivity to any ingredients; if pregnant, consult your health‑care practitioner before use.

Drug Interaction

Methotrexate interaction

Not recommended concurrently with methotrexate cancer therapy (may interfere with anti‑neoplastic activity); does not interfere with methotrexate’s anti‑inflammatory activity—individuals taking methotrexate for psoriasis or rheumatoid arthritis can safely take folate supplements.

Product education

5-MTHF 1 mg: A Bioactive Folate for Mood, Heart, and Nerve Health

Thorne’s 5-MTHF provides a 1-mg dose of L-5-Methyltetrahydrofolate, the most active, bioavailable form of folate. As an essential B vitamin, folate is crucial for a wide range of bodily processes, including neurotransmitter production, cardiovascular health, and healthy fetal development. However, a significant portion of the population has a genetic variation (MTHFR) that makes it difficult to convert standard folic acid into its active form. This formula bypasses that genetic hurdle, providing a tissue-ready folate for everyone.*

How It Works: The Power of Methylation

5-MTHF is a primary “methyl donor,” which is a fundamental process that supports countless functions throughout the body.*

Support for Mood and Brain Health
Healthy methylation is essential for the synthesis of key neurotransmitters like serotonin, dopamine, and norepinephrine. By providing a direct source of active folate, 5-MTHF supports a healthy mood, promotes a positive outlook, and supports overall cognitive function. It is a cornerstone nutrient for a well-balanced nervous system.*

Promoting Cardiovascular Wellness
This active folate is also crucial for helping to maintain a healthy level of homocysteine, an amino acid that can be harmful to blood vessels at elevated levels. In addition, it plays a vital role in the formation of red blood cells and is particularly important for women of childbearing age to support healthy fetal brain and spinal cord development.*

  • Provides the active, methylated form of folate for superior bioavailability*
  • Ideal for individuals with an MTHFR gene variation
  • Supports a positive mood and healthy neurotransmitter production*
  • Helps maintain healthy homocysteine levels for cardiovascular support*
  • Essential for healthy fetal development and red blood cell formation

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Serving Size: One Capsule
Servings Per Container: 60
Ingredient Amount %DV
Folate (1 mg as L-5-Methyltetrahydrofolate†) 1.7 mg DFE 425%
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
*Daily Value (DV) not established.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.