Thorne Research

5-Hydroxytryptophan

$39.00

SIZE: 90 Capsules

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The Promise

Product identity & core formulation Standardized precursor plus active B6 cofactor

5-Hydroxytryptophan (5-HTP) from Griffonia seed with pyridoxal-5′-phosphate (P‑5‑P) in vegetarian capsules.

Ingredient identity

5‑Hydroxytryptophan (5‑HTP) sourced from Griffonia simplicifolia seeds.

Active cofactor

Includes vitamin B6 as pyridoxal‑5′‑phosphate (P‑5‑P), the bioactive form of B6.

Dosage form

Vegetarian hypromellose (cellulose-derived) capsules.

Manufacturing & additives

Per serving: microcrystalline cellulose, leucine, silicon dioxide; no animal gelatin.

Why It Works

Key formulation facts Quantities, forms, and serving basis you can verify

Concrete amounts and forms listed on the Supplement Facts and label instructions.

01

5‑HTP amount per serving

Serving size = two capsules; contains 100 mg 5‑Hydroxytryptophan per serving.

02

Vitamin B6 amount & form

Provides 6.8 mg vitamin B6 as pyridoxal‑5′‑phosphate (P‑5‑P) — 400% Daily Value per serving.

03

Capsule composition

Hypromellose capsule (derived from cellulose) — labeled vegetarian capsule material.

04

Other ingredient listing

Includes microcrystalline cellulose, leucine, silicon dioxide as excipients.

Reviews

Customer Reviews

Your Journey

How to use & safety checkpoints Label directions and explicit warnings to follow

Follow labeled serving, timing, and contraindications; consult your practitioner as directed.

Serving & timing

Recommended use

Take 1–2 capsules three times daily or as recommended by your health‑care practitioner. Serving size listed as two capsules.

Pack size

Servings per container

Each container yields 45 servings per label (serving = two capsules).

Warnings & contraindications

When not to use

Contraindicated if pregnant or nursing; contraindicated with a history of hypersensitivity to any ingredient.

Drug interactions & practitioner note

Medications to avoid concurrently

Do not use concurrently with antidepressants (SSRIs, MAOIs, tricyclics), carbidopa, or tramadol; follow your health‑care practitioner’s guidance.

Product education

5-Hydroxytryptophan: A Serotonin Precursor for Mood and Sleep Support*

Thorne’s 5-Hydroxytryptophan (5-HTP) is a high-quality supplement designed to support a healthy mood, manage stress, and promote restful sleep. 5-HTP is a naturally occurring amino acid that serves as the direct building block for the synthesis of serotonin, a crucial neurotransmitter. This formula is enhanced with the active, most usable form of vitamin B6 (P-5-P), an essential cofactor that the body needs to convert 5-HTP into serotonin. It’s a foundational choice for individuals seeking to naturally support their emotional well-being and sleep patterns.*

How It Works: The Science of Serotonin Production

The brain’s level of serotonin is essential for feelings of well-being. This formula works by providing the direct precursors the body needs to optimize its own serotonin production.

Promoting a Positive Mood and Managing Stress
Serotonin is often called the “feel-good” neurotransmitter because of its significant role in regulating mood and emotions. By providing a direct source of 5-HTP, which readily crosses the blood-brain barrier, this supplement helps to maintain healthy serotonin levels. This can promote a positive outlook, help manage feelings of stress, and support emotional resilience.*

Supporting Restful Sleep Cycles
In the brain, serotonin is converted into melatonin, the body’s primary sleep hormone. Therefore, supporting healthy serotonin levels during the day is a key step in promoting the natural production of melatonin at night. By providing the necessary building blocks, 5-HTP helps to regulate the circadian rhythm, making it easier to fall asleep and achieve a more restorative sleep cycle.*

  • Promotes a positive mood and emotional well-being*
  • Provides the direct precursor for the body’s serotonin production
  • Supports restful sleep by aiding in melatonin synthesis*
  • Includes active Vitamin B6 (P-5-P) to enhance serotonin conversion
  • Sourced from the seeds of the Griffonia simplicifolia plant

Supplement record

Review serving details and ingredients for this product.

Supplement Facts:
Suggested Use: Take 1-2 capsules three times daily or as recommended by your health-care practitioner.
Serving Size: Two Capsules
Servings Per Container: 45
Ingredient Amount %DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 6.8 mg 400%
5-Hydroxytryptophan 100 mg **
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
**Daily Value (DV) not established.
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
WARNING If pregnant or nursing, do not use this product.
INTERACTIONS 5-Hydroxytryptophan is contraindicated for concurrent use with antidepressant medications (SSRIs, MAOIs, tricyclics), carbidopa, or tramadol.