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Methyl-Guard Plus: Advanced Support for Healthy Methylation
Thorne’s Methyl-Guard Plus delivers a powerful, targeted blend of essential nutrients in their most active, bioavailable forms to support the body’s critical methylation pathway. Methylation is a fundamental biochemical process that impacts nearly every cell and organ, influencing everything from cardiovascular and neurological health to detoxification and mood regulation. This formula provides a high-potency combination of B vitamins and betaine to promote healthy homocysteine levels, support neurotransmitter production, and optimize overall wellness for individuals needing more robust methylation support.
How It Works: The Power of Active, Tissue-Ready Nutrients
Many individuals have genetic variations, like those in the MTHFR gene, that can make it difficult to convert standard B vitamins into their active forms. Methyl-Guard Plus bypasses these potential roadblocks by providing nutrients that are ready for your body to use immediately.
Bioactive B Vitamins
This formula features the active forms of folate (L-5-MTHF), vitamin B12 (methylcobalamin), vitamin B6 (P-5-P), and vitamin B2 (riboflavin 5′-phosphate). These B vitamins are crucial “methyl donors” that facilitate the conversion of the potentially harmful amino acid homocysteine into the beneficial amino acid methionine. Maintaining a healthy homocysteine level is vital for cardiovascular health, while proper B vitamin status is essential for producing the neurotransmitters that regulate mood, such as serotonin and dopamine.
Betaine (TMG) for Added Support
To provide even more comprehensive support, Methyl-Guard Plus includes a significant amount of Betaine Anhydrous, also known as TMG (trimethylglycine). Betaine offers an additional pathway for homocysteine metabolism, particularly in the liver, which supports detoxification processes. It also protects against fat accumulation in the liver and provides further support for cardiovascular health. This synergistic formula ensures a multi-faceted approach to maintaining a balanced and efficient methylation cycle.
- ✅ Promotes healthy methylation to support hundreds of bodily processes
- ✅ Helps maintain healthy homocysteine levels for cardiovascular wellness
- ✅ Contains the most bioactive forms of B2, B6, B12, and folate
- ✅ Ideal for individuals with MTHFR gene variants needing methylation support
- ✅ Supports positive mood, detoxification, and nerve health
Product Ingredients
Supplement Facts:
Suggested Use: Take 1-3 capsules daily or as recommended by your health-care practitioner.
Serving Size: Three Capsules
Servings Per Container: 30
| Ingredient | Amount | %DV |
|---|---|---|
| Riboflavin (as Riboflavin 5'-Phosphate Sodium) | 90 mg | 6,923% |
| Vitamin B6 (as Pyridoxal 5'-Phosphate) | 45 mg | 2,647% |
| Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 5 mg DFE | 1,250% |
| Vitamin B12 (as Methylcobalamin) | 3 mg | 125,000% |
| Betaine Anhydrous (Trimethylglycine) | 1.8 g | ** |
Other ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.
*Daily Value (DV) not established.
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health-care practitioner before using this product.
INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
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—Dr. Devin Ryerson
Founder & CEO
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